Abstract
This paper reports the fabrication of multi-functionalized gold nanoparticles (MFAuNPs) and the application to electrochemical detection of nitrite. While gold nanoparticles are modified with thiolated oligonucleotides as usual, they are also immobilized with 5- [1, 2]dithiolan-3-yl-pentanoic acid [2-(naphthalene-1-ylamino)-ethyl]amide (DPAN). Therefore, the oligonucleotides molecules can enhance the solubility of the MFAuNPs and absorb hexaammineruthenium(III) chloride ([Ru(NH3)6]3+) as electrochemical species on the one hand, with the help of nitrite ions, DPAN immobilized on MFAuNPs will react with 4-(2-aminoethyl)benzenamine which has been previously modified on the surface of a gold electrode on the other hand, thus an electrochemical method for nitrite detection is also proposed. Although the maximum contaminant level (MCL) defined by the Environmental Protection Agency (EPA) for nitrite in drinking water is as low as 1 ppm (21.7 μM), which is difficult to make detections by the current techniques, the proposed method in this work can give very satisfactory results.
Keywords: Cyclic voltammograms, detection, DNA, griess reaction, multi-functionalized gold nanoparticles, nitrite
Current Nanoscience
Title: Fabrication of Multi-functionalized Gold Nanoparticles and the Application to Electrochemical Detection of Nitrite
Volume: 7 Issue: 3
Author(s): Peng Miao, Zhiqiang Liang, Lei Liu and Guifang Chen
Affiliation:
Keywords: Cyclic voltammograms, detection, DNA, griess reaction, multi-functionalized gold nanoparticles, nitrite
Abstract: This paper reports the fabrication of multi-functionalized gold nanoparticles (MFAuNPs) and the application to electrochemical detection of nitrite. While gold nanoparticles are modified with thiolated oligonucleotides as usual, they are also immobilized with 5- [1, 2]dithiolan-3-yl-pentanoic acid [2-(naphthalene-1-ylamino)-ethyl]amide (DPAN). Therefore, the oligonucleotides molecules can enhance the solubility of the MFAuNPs and absorb hexaammineruthenium(III) chloride ([Ru(NH3)6]3+) as electrochemical species on the one hand, with the help of nitrite ions, DPAN immobilized on MFAuNPs will react with 4-(2-aminoethyl)benzenamine which has been previously modified on the surface of a gold electrode on the other hand, thus an electrochemical method for nitrite detection is also proposed. Although the maximum contaminant level (MCL) defined by the Environmental Protection Agency (EPA) for nitrite in drinking water is as low as 1 ppm (21.7 μM), which is difficult to make detections by the current techniques, the proposed method in this work can give very satisfactory results.
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Cite this article as:
Miao Peng, Liang Zhiqiang, Liu Lei and Chen Guifang, Fabrication of Multi-functionalized Gold Nanoparticles and the Application to Electrochemical Detection of Nitrite, Current Nanoscience 2011; 7 (3) . https://dx.doi.org/10.2174/157341311795542345
DOI https://dx.doi.org/10.2174/157341311795542345 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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