Abstract
Superoxide dismutases (SODs) are a family of important antioxidant enzymes that catalyze the conversion of superoxide to hydrogen peroxide and oxygen. Hydrogen peroxide is then detoxified by a host of antioxidant enzymes. A common misconception is that the increased MnSOD levels will result in increased hydrogen peroxide levels. Herein we offer some potential reasons for this confusion, as well as some potential resolutions. Data are offered that demonstrate the ability of MnSOD, in the presence of nitric oxide, to utilize hydrogen peroxide to produce superoxide and the more toxic oxidant, peroxynitrite.
Keywords: MnSOD, superoxide, hydrogen peroxide, nitric oxide, peroxynitrite, oxidant-sensitive fluorophore, metalloproteinases, H2O2, ONOO, nanomolar concentrations, DCDHF, proliferation, ischemia/reperfusion injury, horseradish peroxidase or HRP
Anti-Cancer Agents in Medicinal Chemistry
Title: Does More MnSOD Mean More Hydrogen Peroxide?
Volume: 11 Issue: 2
Author(s): Lee Ann MacMillan-Crow and John P. Crow
Affiliation:
Keywords: MnSOD, superoxide, hydrogen peroxide, nitric oxide, peroxynitrite, oxidant-sensitive fluorophore, metalloproteinases, H2O2, ONOO, nanomolar concentrations, DCDHF, proliferation, ischemia/reperfusion injury, horseradish peroxidase or HRP
Abstract: Superoxide dismutases (SODs) are a family of important antioxidant enzymes that catalyze the conversion of superoxide to hydrogen peroxide and oxygen. Hydrogen peroxide is then detoxified by a host of antioxidant enzymes. A common misconception is that the increased MnSOD levels will result in increased hydrogen peroxide levels. Herein we offer some potential reasons for this confusion, as well as some potential resolutions. Data are offered that demonstrate the ability of MnSOD, in the presence of nitric oxide, to utilize hydrogen peroxide to produce superoxide and the more toxic oxidant, peroxynitrite.
Export Options
About this article
Cite this article as:
Ann MacMillan-Crow Lee and P. Crow John, Does More MnSOD Mean More Hydrogen Peroxide?, Anti-Cancer Agents in Medicinal Chemistry 2011; 11 (2) . https://dx.doi.org/10.2174/187152011795255939
DOI https://dx.doi.org/10.2174/187152011795255939 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Regulation of Angiotensin II Receptor Expression
Current Pharmaceutical Design Daunorubicin Metabolism in Leukemic Cells Isolated from Patients with Acute Myeloid Leukemia
Drug Metabolism Letters Magnesium and Anaesthesia
Current Drug Targets Flavonoids and Chagas' Disease: The Story So Far!
Current Topics in Medicinal Chemistry Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models
Current Neuropharmacology Cardiovascular Magnetic Resonance T2-weighted Imaging of Myocardial Edema in Acute Myocardial Infarction
Recent Patents on Cardiovascular Drug Discovery New Perspective Therapy of Breast Cancer Based on Selective Dopamine Receptor D2 Agonist and Antagonist Effects on MCF-7 Cell Line
Recent Patents on Anti-Cancer Drug Discovery Blockade of Apoptosis by ACE Inhibitors and Angiotensin Receptor Antagonists
Current Pharmaceutical Design Inverse Regulation of MMP-9 and MMP-2 in Long-Term Follow-up After Acute Coronary Syndrome: Lack of Correlation with Platelet and Endothelial Cell Activation Markers
Vascular Disease Prevention (Discontinued) Targeting miRNAs for Drug Discovery: A New Paradigm
Current Molecular Medicine Fibrates in the Chemical Action of Daunorubicin
Current Cancer Drug Targets New Strategies for Managing Anemia of Chronic Kidney Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Etiopathogenesis, Classical Immunotherapy and Innovative Nanotherapeutics for Inflammatory Neurological Disorders
Current Nanoscience Influence of a High-Fat Diet on Cardiac iNOS in Female Rats
Current Vascular Pharmacology Reactive Oxygen and Nitrogen Species in the Renal Ischemia/Reperfusion Injury
Current Pharmaceutical Design The Two fACEs of the Tissue Renin-Angiotensin Systems: Implication in Cardiovascular Diseases
Current Pharmaceutical Design Editorial (Thematic Issue: Therapeutic Interventions Against Trypanosomiasis)
Current Topics in Medicinal Chemistry Calcium Homeostasis and Kinetics in Heart Failure
Medicinal Chemistry The Metabolic Syndrome and the Relevance of Nutrients for its Onset
Recent Patents on Biotechnology Role of CD73 in Disease: Promising Prognostic Indicator and Therapeutic Target
Current Medicinal Chemistry