Generic placeholder image

Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese

Author(s): Yasuhisa Fukuo, Nakao Iwata, Hiroshi Ujike, Norio Ozaki, Ichiro Sora, Masaomi Iyo, Naohisa Uchimura, Mitsuhiko Yamada, Toshiya Inada, Takenori Okumura, Tomoko Tsunoka, Kunihiro Kawashima, Yoko Kinoshita, Tsuyoshi Kitajima, Masashi Ikeda, Taro Kishi and Tomo Okochi

Volume 9 , Issue 1 , 2011

Page: [155 - 159] Pages: 5

DOI: 10.2174/157015911795017308

Price: $65


The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important roles as a gaseous neurotransmitter in brain. NO is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related to the dopaminergic system. Because the symptomatology of methamphetamine (METH) use disorder patients with psychosis is similar to that of patients with schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis. Therefore, we conducted a case-control association study between NOS1 and METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221, rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous reports. Written informed consent was obtained from each subject. This study was approved by the Ethics Committee at Fujita Health University School of Medicine and each participating institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). No significant association was found between NOS1 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS1 might not contribute to the risk of METH-induced psychosis in the Japanese population.

Keywords: Methamphetamine-induced psychosis, neuronal nitric oxide synthase 1 gene (NOS1), case-control association study, case-control association, serotonin, mesolimbic system, schizophrenia, neurotransmitters, psychotic disorders, comorbid diagnosis, anxiety disorder, mood disorder, METH-induced psychosis, NOS1

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy