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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Contribution of Inflammation to Fat Redistribution and Metabolic Disturbances in HIV-1 Infected Patients

Author(s): Metodi V. Stankov and Georg M.N. Behrens

Volume 16 , Issue 30 , 2010

Page: [3361 - 3371] Pages: 11

DOI: 10.2174/138161210793563473

Price: $65

Abstract

Antiretroviral therapy (ART) has significantly reduced the morbidity and mortality of patients infected with the human immunodeficiency virus 1 (HIV-1). In a significant number of patients, ART is associated with fat redistribution and metabolic alterations such as dyslipidemia, insulin resistance (IR) and type 2 diabetes, summarized under the term HIV-associated lipodystrophy syndrome (HIVLS). The pathogenesis of HIV-LS is complex and involves a number of factors including ART, HIV-1, abnormal fat redistribution, metabolic abnormalities and chronic inflammation. In view of a novel understanding on how chronic inflammation contributes to the pathogenesis of HIV-1 infection, this review focuses on the interaction of the immune system and metabolic pathways and the potential consequences for the HIV-LS. Based on the current literature, we suggest a central role of systemic inflammation in triggering and deteriorating various components of the HIV-LS.

Keywords: Antiretroviral therapy, HIV-1, fat redistribution, metabolic syndrome, chronic inflammation


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