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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Potentialities of Induced Pluripotent Stem (iPS) Cells for Treatment of Diseases

Author(s): C. Chakraborty, K. D. Shah, W. G. Caob, C. H. Hsu, Z. H. Wen and C. S. Lin

Volume 10 , Issue 8 , 2010

Page: [756 - 762] Pages: 7

DOI: 10.2174/156652410793384178

Price: $65


Induced pluripotent stem (iPS) cell research has been growing a new height throughout the world due to its potentialities in medical applications. We can explore several therapeutic applications through the iPS cell research. In this review, we have first discussed the development of iPS cells, reprogramming factors, and effectiveness of iPS cells. Then we have emphasized the potential applications of iPS cells in pharmaceutical and medical sectors, such as, study of cellular mechanisms for spectrum of disease entities, disease-specific iPS cell lines for drugs discovery and development, toxicological studies of drugs development, personalized medicine, and regenerative medicine.

Keywords: Induced pluripotent stem (iPS) cell, disease-specific iPS cell lines, drug discovery and development, toxicological studies, personalized medicine, regenerative medicine, Yamanaka Factors, blastomeres, HMG-box, histone acetyltransferases, c-Myc, Nanog, pluripotency, retrovirus, lentivirus, doxycycline, keratinocytes, neurodegenerative disorders, amyotrophic lateral sclerosis, spinal muscular atrophy, Huntington's disease, Alzheimer's disease, Parkinson's disease, Anderson-Fabry disease, transplantation

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