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Current Neuropharmacology



ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Aquaporins in Sensory and Pain Transmission

Author(s): Elisa Borsani

Volume 8 , Issue 2 , 2010

Page: [122 - 127] Pages: 6

DOI: 10.2174/157015910791233187

Price: $65


Recent data suggest a possible involvement of Aquaporins (AQPs) in pain transmission. AQPs are small membrane channel proteins involved in osmoregulation and, to date, AQP1, AQP2, AQP3, AQP4, AQP5, AQP8 and AQP9 have been found in the nervous system. Nevertheless only AQP1, AQP2 and AQP4 seem to be involved in nociception. In this review, direct and indirect evidences of the role of AQPs in pain processing will be reported.

Keywords: Aquaporins, nervous system, sensory transmission, pain transmission

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