Abstract
Cardiac fibrosis occurs in response to numerous factors including ischemia, myocardial scarring after infarction, pressure overload of the heart, and a complex interplay of multiple hormonal systems. Transforming growth factor-beta (TGF-β) is a locally generated cytokine that participates in healing processes and tissue fibrosis following cardiac injury. TGF-β1 induces the proliferation of cardiac fibroblasts and their phenotypic transformation to myofibroblasts, and the deposition of extracellular matrix (ECM). This review examines current knowledge on TGF-β signal transduction pathways and the effects of TGF-β inhibition on the development of cardiac fibrosis. Improved understanding of the actions and signaling of this cytokine system may lead to the development of new therapeutic strategies that combat the development of myocardial fibrosis in the pathogenesis of heart failure.
Keywords: Transforming growth factor-beta, inhibition, cardiac fibrosis
Current Enzyme Inhibition
Title: The Role of Transforming Growth Factor-β in Cardiac Fibrosis
Volume: 6 Issue: 2
Author(s): Leigh J. Ellmers
Affiliation:
Keywords: Transforming growth factor-beta, inhibition, cardiac fibrosis
Abstract: Cardiac fibrosis occurs in response to numerous factors including ischemia, myocardial scarring after infarction, pressure overload of the heart, and a complex interplay of multiple hormonal systems. Transforming growth factor-beta (TGF-β) is a locally generated cytokine that participates in healing processes and tissue fibrosis following cardiac injury. TGF-β1 induces the proliferation of cardiac fibroblasts and their phenotypic transformation to myofibroblasts, and the deposition of extracellular matrix (ECM). This review examines current knowledge on TGF-β signal transduction pathways and the effects of TGF-β inhibition on the development of cardiac fibrosis. Improved understanding of the actions and signaling of this cytokine system may lead to the development of new therapeutic strategies that combat the development of myocardial fibrosis in the pathogenesis of heart failure.
Export Options
About this article
Cite this article as:
J. Ellmers Leigh, The Role of Transforming Growth Factor-β in Cardiac Fibrosis, Current Enzyme Inhibition 2010; 6 (2) . https://dx.doi.org/10.2174/157340810791233024
DOI https://dx.doi.org/10.2174/157340810791233024 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
MRI of Pancreas in Patients with Chronic Pancreatitis and Healthy Volunteers: Can Pancreatic Signal Intensity and Contrast Enhancement Patterns be Valuable Predictors of Early Chronic Pancreatitis?
Current Medical Imaging Current Strategies and Drug Targets in the Management of Type 2 Diabetes Mellitus
Current Drug Targets Thyroid Hormone-Induced Angiogenesis
Current Cardiology Reviews Prevention and Therapeutic Strategies of Thromboembolic Events in Patients with Inflammatory Bowel Diseases: A Report of Three Cases
Current Drug Targets Ability of older people with dementia or cognitive impairment to manage medicine regimens: a narrative review
Current Clinical Pharmacology Longevity Pathways: HSF1 and FoxO Pathways, a New Therapeutic Target to Prevent Age-Related Diseases
Current Aging Science Deciphering the Physiology Underlying the Rapid Clinical Effects of Perispinal Etanercept in Alzheimers Disease
Current Alzheimer Research The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II
Current Medicinal Chemistry Magnetic Bead-based Proteome Profiling Using MALDI-TOF Spectrometry in Cardiac Tissue from Transgenic Mice
Current Proteomics Emerging Anticoagulants
Current Medicinal Chemistry Hypertension in the Elderly
Cardiovascular & Hematological Agents in Medicinal Chemistry Bioactive Compounds in Diabetic Cardiomyopathy: Current Approaches and Potential Diagnostic and Therapeutic Targets
Cardiovascular & Hematological Agents in Medicinal Chemistry Anti Tumor Necrosis Factor Alpha (TNFα) Therapy in Ankylosing Spondylitis - Asian Perspective
Current Rheumatology Reviews The Renin-angiotensin System as a Target of Novel Anticancer Therapy
Current Pharmaceutical Design Use of Mesenchymal Stem Cells in Crohn's Disease and Perianal Fistulas: A Narrative Review
Current Stem Cell Research & Therapy MicroRNAs and the Heart: Small Things Do Matter
Current Topics in Medicinal Chemistry Evaluation Approach can Significantly Influence Oral Glucose-Lowering Drugs Total Mortality Risks in Retrospective Cohorts of Type 2 Diabetes Mellitus Patients
Current Diabetes Reviews MicroRNAs in Genetic Disease: Rethinking the Dosage
Current Gene Therapy Radiological Screening Programs for Women at High Risk of Developing Breast Cancer
Current Women`s Health Reviews Computational Methods and Algorithms for Mass Spectrometry Based Differential Proteomics: Recent Advances, Perspectives and Open Problems
Current Proteomics