Pipeline Pharmacogenetics: A Novel Approach to Integrating Pharmacogenetics into Drug Development

Title: Pipeline Pharmacogenetics: A Novel Approach to Integrating Pharmacogenetics into Drug Development

Volume: 15 Issue: 32

Author(s): P. Anthony Akkari, Thomas W. Swanson, Donna G. Crenshaw, Iris Grossman, Scott Sundseth, Daniel K. Burns and Allen D. Roses

Affiliation:

Keywords: Stratified medicine, Pipeline pharmacogenetics, drug development, in vitro diagnostic (IVD), safety, efficacy, Cabernet Pharmaceuticals, Shiraz Pharmaceuticals, Zinfandel Pharmaceuticals

Abstract: There has been a decline in the number of new drugs registered over the past decade and regulatory concerns for safety as well as payer concerns for efficacy have focused attention on stratified medicine. Integration of pharmacogenetics into the drug development pipeline will contribute to the development of new stratified drugs. We describe here the concept of pipeline pharmacogenetics and its application throughout the phases of drug discovery. Pipeline pharmacogenetics enables the evaluation of the genetic contribution to safety potentially lowering barriers to registration as well as providing rationale for efficacy and enabling co-development of genetic in vitro diagnostics.

Cite this article as:

Akkari Anthony P., Swanson W. Thomas, Crenshaw G. Donna, Grossman Iris, Sundseth Scott, Burns K. Daniel and Roses D. Allen, Pipeline Pharmacogenetics: A Novel Approach to Integrating Pharmacogenetics into Drug Development, Current Pharmaceutical Design 2009; 15 (32) . https://dx.doi.org/10.2174/138161209789649538