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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

The Role of ING Tumor Suppressors in UV Stress Response and Melanoma Progression

Author(s): Jun Li, Yemin Wang, Ronald P.C. Wong and Gang Li

Volume 10 , Issue 5 , 2009

Page: [455 - 464] Pages: 10

DOI: 10.2174/138945009788185031

Price: $65

Abstract

The INhibitor of Growth (ING) genes were discovered during the past decade and identified as type II tumor suppressor genes. Previous studies demonstrated that ING family members participate in various cellular stress responses and thus play important roles in the pathogenesis of various types of cancers, including melanoma. Epidemiological studies showed that UV radiation is the primary etiological factor in melanoma development. Here we review the studies on the role of ING proteins in cellular responses to UV irradiation, melanoma cell motility, and melanoma progression.

Keywords: ING, tumor suppressor, melanoma, UV irradiation, stress response


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