Abstract
The advent of post genomic technologies and their application to biomedical problems resulted in a massive increase the complexity of data generated. This has resulted in the need for more refined statistical and computational methods for analysis of this type of data Through comprehensive analysis and modelling approaches, structures or classes in the data can be defined, denovo predictive biomarkers identified and clinical decision support systems developed. This review seeks to provide an overview of some of the computational methodologies that have been used for data-mining complex high throughput data for the identification of new biomarkers or improvement of existing biomarkers. Given the literature is vast within the area of computational algorithms we seek to present commonly used methods.
Keywords: Biomarkers, ANN, SVM, logistic regression
Current Cancer Therapy Reviews
Title: Computational & Statistical Methodologies to Identify Biomarkers in Cancer
Volume: 4 Issue: 2
Author(s): Graham R. Ball
Affiliation:
Keywords: Biomarkers, ANN, SVM, logistic regression
Abstract: The advent of post genomic technologies and their application to biomedical problems resulted in a massive increase the complexity of data generated. This has resulted in the need for more refined statistical and computational methods for analysis of this type of data Through comprehensive analysis and modelling approaches, structures or classes in the data can be defined, denovo predictive biomarkers identified and clinical decision support systems developed. This review seeks to provide an overview of some of the computational methodologies that have been used for data-mining complex high throughput data for the identification of new biomarkers or improvement of existing biomarkers. Given the literature is vast within the area of computational algorithms we seek to present commonly used methods.
Export Options
About this article
Cite this article as:
Ball R. Graham, Computational & Statistical Methodologies to Identify Biomarkers in Cancer, Current Cancer Therapy Reviews 2008; 4 (2) . https://dx.doi.org/10.2174/157339408784310043
DOI https://dx.doi.org/10.2174/157339408784310043 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Targeting p73 - a Potential Approach in Cancer Treatment
Current Pharmaceutical Design Functions of S100 Proteins
Current Molecular Medicine History of Autoimmune Pancreatitis and Mikuliczs Disease
Current Immunology Reviews (Discontinued) Development, Validation, and Applications of Anisotropic Polarizable Molecular Mechanics to Study Ligand and Drug-Receptor Interactions
Current Pharmaceutical Design The Role of E-Cadherin Down-Regulation in Oral Cancer: CDH1 Gene Expression and Epigenetic Blockage
Current Cancer Drug Targets Adipose-Derived Stromal/Stem Cells (ASC) in Regenerative Medicine: Pharmaceutical Applications
Current Pharmaceutical Design Clinical Studies with Targeted Toxins in Malignant Glioma
Reviews on Recent Clinical Trials Modulation of Matrix Metalloproteinases by Plant-derived Products
Current Cancer Drug Targets The Next Step in Voice Assessment: High-Speed Digital Endoscopy and Objective Evaluation
Current Bioinformatics Specific Hemosiderin Deposition in Spleen Induced by a Low Dose of Cisplatin: Altered Iron Metabolism and Its Implication as an Acute Hemosiderin Formation Model
Current Drug Metabolism Mitogenomics: Recognizing the Significance of Mitochondrial Genomic Variation for Personalized Medicine
Current Pharmacogenomics and Personalized Medicine Living Life to the Fullest: Early Integration of Palliative Care into the Lives of Children with Chronic Complex Conditions
Current Pediatric Reviews Monoclonal Antibodies as Cancer Therapeutics
Recent Patents on Biotechnology Resveratrol-Mediated Reversal of Tumor Multi-Drug Resistance
Current Drug Metabolism Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients. Five Years Literature Review
Reviews on Recent Clinical Trials Micro- and Nano-particulate Strategies for Antigen Specific Immune Tolerance to Treat Autoimmune Diseases
Pharmaceutical Nanotechnology Oncogenic LncRNA CASC9 in Cancer Progression
Current Pharmaceutical Design Drug Therapy of Neuropathic Pain: Current Developments and Future Perspectives
Current Drug Targets Glucose Sensing in Chondrocytes via GLUT1 and GLUT3: Implications for Articular Cartilage and Intervertebral Disc Metabolism
Current Rheumatology Reviews An Insight of Molecular Mechanisms and Patents of Biomarkers of Human Papilloma Virus Associated with Cancer : A Review
Recent Patents on Biomarkers