Thiazolidinedione: A Privileged Scaffold for the Development of Anticancer Agents

Title:Thiazolidinedione: A Privileged Scaffold for the Development of Anticancer Agents

Volume: 21 Issue: 28

Author(s): Juan Sun, Yue-Hu Chen, Han-Yu Liu, Emmerson Hondo, Yang Zhou*Yuan-Feng Wu*

Affiliation:

• Zhejiang Engineering Research Center for Biomedical Materials, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315300,China

• School of Biological & Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023,China

Keywords: Thiazolidinedione, Anticancer, Structure-activity relationship, 3D-QSAR, Inhibitors, Molecular Docking.

Abstract: Thiazolidinedione, an important heterocyclic ring system, is a pharmacophore and a privileged scaffold in medicinal chemistry. Researchers have shown its potential application as a backbone for inhibitors, as it is involved in anticancer development strategies, cancer progression and metastasis. In this paper, the anticancer activities of thiazolidinedione derivatives were reviewed for the first time with respect to different substituents and their positions. This work may imitate a stirring wheel to guide further advanced development of new anticancer molecules with high efficacy.

Cite this article as:

Sun Juan , Chen Yue-Hu , Liu Han-Yu , Hondo Emmerson , Zhou Yang *, Wu Yuan-Feng *, Thiazolidinedione: A Privileged Scaffold for the Development of Anticancer Agents, Current Topics in Medicinal Chemistry 2021; 21 (28) . https://dx.doi.org/10.2174/1568026621666210521143550