Several decades of investigation concerning the cause and cure of cancer have revealed major discrepancies in the response of different cancer types towards a particular therapy and therefore a need for more effective approaches has been conceived. It is known that cancer development irrespective of its origin occurs due to the compromises that normal cells make in critical pathways, thereby allowing to transform into a tumor. It is thus conceivable that the most effective cancer therapy requires multiple targeting of molecular alterations responsible for malignant transformation. In this context, the development of combinational therapies aimed at multi-cornered attack on cancer cells is of particular significance. The present article is a brief review of the novel trends emerging in cancer therapeutics with special emphasis on epigenetic therapy, cancer stem cell therapy, modern radiotherapy, target based cancer therapy and polyphenol therapy.