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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Properties of Ethnomedicinal Plants and Their Bioactive Compounds: Possible Use for COVID-19 Prevention and Treatment

Author(s): Ambreen Shoaib, Lubna Azmi, Ila Shukla, Saad S. Alqahtani, Ibrahim A. Alsarra and Faiyaz Shakeel*

Volume 27 , Issue 13 , 2021

Published on: 06 November, 2020

Page: [1579 - 1587] Pages: 9

DOI: 10.2174/1381612826666201106092021

Price: $65

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has changed the global scenario. To date, there are no treatment or preventive options. The discovery of a new drug will take time. In addition, the new drug will have side effects, and the virus will gradually become resistant to it. Therefore, it is important to search for a drug with a natural origin.

Objective: In this review, we analyzed and summarized various ethnomedicinal plants and their bioactive compounds as a source of antiviral agents for COVID-19 prevention and treatment.

Methods: From the literature, we selected different natural compounds that can act as potential targets at low cost with broad-spectrum antiviral activity.

Results: Of the 200 Chinese herbal extracts tested for their possible role against SARS-CoV, Lycoris radiata, Artemisia annua, Pyrrosia lingua, and Lindera aggregate showed anti-SARS-CoV effects with the median effective concentration = 2.4-88.2 μg/mL.

Conclusion: Ethnomedicinal herbs can be used as an alternative source of novel, promising antiviral agents that might directly or indirectly inhibit the COVID-19 progression.

Keywords: Anthocyanins, COVID-19, Middle East respiratory syndrome, Nigella sativa, Pandemic, SARS-CoV.


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