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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Lipases as Modulators of Atherosclerosis in Murine Models

Author(s): Robert J. Brown and Daniel J. Rader

Volume 8 , Issue 12 , 2007

Page: [1307 - 1319] Pages: 13

DOI: 10.2174/138945007783220614

Price: $65

Abstract

Lipoprotein lipase, hepatic lipase, and endothelial lipase are sn-1 lipases that play important roles in the metabolism of plasma lipoproteins. In vitro and in vivo studies suggest that these lipases exhibit both pro- and antiatherogenic properties, which are dependent primarily on their tissue localization. The following chapter reviews the physiology of these lipases, and the consequences of the loss or gain of function for each lipase in modulating atherosclerosis, with emphasis on murine models.

Keywords: Lipase, lipoprotein, aortic lesion, coronary artery disease, atherosclerosis, transgenic mouse, knockout mouse


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