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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Oxidative Stress as a Regulator of Murine Atherosclerosis

Author(s): Tzung Hsiai and Judith A. Berliner

Volume 8 , Issue 12 , 2007

Page: [1222 - 1229] Pages: 8

DOI: 10.2174/138945007783220678

Price: $65

Abstract

Altered cellular production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) is a ubiquitous feature of human disease. Vascular oxidative stress is a unifying area of research in atherosclerosis and aging. While elevated levels of ROS, especially oxygen radicals (O2 -·) and hydrogen peroxide (H2O2), induce cellular apoptosis, low levels play an important role in cell signaling [1,2]. Reactive species from a variety of sources further play an important role in plaque disruption partly through lipid oxidation, low-density lipoprotein oxidation nitration, and signaling [3- 6].

Keywords: NADPH Oxidase, dihydroethidium, superoxide dismutase, Lipoxygenase, xanthine oxidase


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