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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Phytochemicals for Drug Discovery in Alzheimer’s Disease: In Silico Advances

Author(s): Smriti Sharma and Vinayak Bhatia*

Volume 27 , Issue 25 , 2021

Published on: 28 September, 2020

Page: [2848 - 2860] Pages: 13

DOI: 10.2174/1381612826666200928161721

Price: $65

Abstract

The search for novel drugs that can prevent or control Alzheimer’s disease has attracted a lot of attention from researchers across the globe. Phytochemicals are increasingly being used to provide scaffolds to design drugs for AD. In silico techniques have proven to be a game-changer in this drug design and development process. In this review, the authors have focussed on current advances in the field of in silico medicine, applied to phytochemicals, to discover novel drugs to prevent or cure AD. After giving a brief context of the etiology and available drug targets for AD, authors have discussed the latest advances and techniques in computational drug design of AD from phytochemicals. Some of the prototypical studies in this area are discussed in detail. In silico phytochemical analysis is a tool of choice for researchers all across the globe and helps integrate chemical biology with drug design.

Keywords: In silico medicine, computational drug design, Alzheimer's disease, phytochemicals, molecular modelling, drug targets.


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