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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Perspective of Molecular Hydrogen in the Treatment of Sepsis

Author(s): Bo Qi, Yang Yu, Yaoqi Wang, Yuzun Wang, Yonghao Yu and Keliang Xie*

Volume 27 , Issue 5 , 2021

Published on: 09 September, 2020

Page: [667 - 678] Pages: 12

DOI: 10.2174/1381612826666200909124936

Price: $65

Abstract

Sepsis is the main cause of death in critically ill patients with no effective treatment. Sepsis is lifethreatening organ dysfunction due to a dysregulated host response to infection. As a novel medical gas, molecular hydrogen (H2) has a therapeutic effect on many diseases, such as sepsis. H2 treatment exerts multiple biological effects, which can effectively improve multiple organ injuries caused by sepsis. However, the underlying molecular mechanisms of hydrogen involved in the treatment of sepsis remain elusive, which are likely related to anti-inflammation, anti-oxidation, anti-apoptosis, regulation of autophagy and multiple signaling pathways. This review can help better understand the progress of hydrogen in the treatment of sepsis, and provide a theoretical basis for the clinical application of hydrogen therapy in sepsis in the future.

Keywords: Sepsis, molecular hydrogen, organ injury, inflammation, oxidative stress, mechanisms.

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