Abstract
Diabetes is a chronic disease characterized by marked alterations in the metabolism of glucose and by high concentrations of glucose in the blood due to a decreased insulin production or resistance to the action of this hormone in peripheral tissues. The International Diabetes Federation estimates a global incidence of diabetes of about 10% in the adult population (20 - 79 years old), some 430 million cases reported worldwide in 2018. It is well documented that people with diabetes have a higher susceptibility to infectious diseases and therefore show higher morbidity and mortality compared to the non-diabetic population. Given that the innate immune response plays a fundamental role in protecting against invading pathogens through a myriad of humoral and cellular mechanisms, the present work makes a comprehensive review of the innate immune alterations in patients with type 2 diabetes mellitus (T2D) as well as a brief description of the molecular events leading or associated to such conditions. We show that in these patients a compromised innate immune response increases susceptibility to infections.
Keywords: Innate response, phagocytosis, Type 2 Diabetes Mellitus, infection, antimicrobial peptide, innate immune cells.
Current Molecular Medicine
Title:Innate Immunity Alterations in Type 2 Diabetes Mellitus: Understanding Infection Susceptibility
Volume: 21 Issue: 4
Author(s): Fátima de Lourdes Ochoa-González, Irma E. González-Curiel, Alberto R. Cervantes-Villagrana, Julio C. Fernández-Ruiz and Julio E. Castañeda-Delgado*
Affiliation:
- Unidad de Investigacion Biomedica de Zacatecas, Instituto Mexicano del Seguro Social (IMSS), Zacatecas, Zac.,Mexico
Keywords: Innate response, phagocytosis, Type 2 Diabetes Mellitus, infection, antimicrobial peptide, innate immune cells.
Abstract: Diabetes is a chronic disease characterized by marked alterations in the metabolism of glucose and by high concentrations of glucose in the blood due to a decreased insulin production or resistance to the action of this hormone in peripheral tissues. The International Diabetes Federation estimates a global incidence of diabetes of about 10% in the adult population (20 - 79 years old), some 430 million cases reported worldwide in 2018. It is well documented that people with diabetes have a higher susceptibility to infectious diseases and therefore show higher morbidity and mortality compared to the non-diabetic population. Given that the innate immune response plays a fundamental role in protecting against invading pathogens through a myriad of humoral and cellular mechanisms, the present work makes a comprehensive review of the innate immune alterations in patients with type 2 diabetes mellitus (T2D) as well as a brief description of the molecular events leading or associated to such conditions. We show that in these patients a compromised innate immune response increases susceptibility to infections.
Export Options
About this article
Cite this article as:
de Lourdes Ochoa-González Fátima , González-Curiel E. Irma, Cervantes-Villagrana R. Alberto , Fernández-Ruiz C. Julio and Castañeda-Delgado E. Julio*, Innate Immunity Alterations in Type 2 Diabetes Mellitus: Understanding Infection Susceptibility, Current Molecular Medicine 2021; 21 (4) . https://dx.doi.org/10.2174/1566524020999200831124534
DOI https://dx.doi.org/10.2174/1566524020999200831124534 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Influences of Maternal Nutritional Status on Vascular Function in the Offspring
Current Drug Targets Advances in the Physiology of GPR55 in the Central Nervous System
Current Neuropharmacology Meet Our Co-Editor
Current Immunology Reviews (Discontinued) Anti-Apoptotic Effect of Human Telomerase Reverse Transcriptase on Endothelial Cells under Oxidative Stress, Independent of Telomere Elongation and Telomerase Activity
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Interatrial Block in the Modern Era
Current Cardiology Reviews Why Does Obesity Increase the Risk for Cardiovascular Disease?
Current Pharmaceutical Design Anti-Diabetic Effect of a Flavonoid and Sitosterol - Rich Aqueous Extract of <i>Pleurotus tuberregium</i> Sclerotia in Alloxan-Induced Diabetic Rabbits
Endocrine, Metabolic & Immune Disorders - Drug Targets Cyclosporin and Organ Specific Toxicity: Clinical Aspects, Pharmacogenetics and Perspectives
Current Clinical Pharmacology Phenolic Compounds as Antioxidants: Carbonic Anhydrase Isoenzymes Inhibitors
Mini-Reviews in Medicinal Chemistry Glucagon and Glucagon-Like Peptide Receptors as Drug Targets
Current Pharmaceutical Design Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets Preface:
Current Psychopharmacology Searching for Phytoinsulins as Cardiovascular Protector in Metabolic Syndrome
Current Pharmaceutical Design The Involvement of Uric Acid in the Pathogenesis of Preeclampsia
Current Hypertension Reviews The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery
Medicinal Chemistry Targeting the Toll-System in Cardiovascular Sciences
Recent Patents on Inflammation & Allergy Drug Discovery Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hepatocellular Carcinoma
Current Molecular Pharmacology Propranolol Safety Profile in Children
Current Drug Safety Arterial Accelerated Aging in Dialysis Patients: The Clinical Impact of Vascular Calcification
Current Vascular Pharmacology Mitochondria in Chronic Liver Disease
Current Drug Targets