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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Research Article

Evaluation of the Oxidative Stress Level and Serum Prolidase Activity in Patients with Sleep Bruxism

Author(s): Ayse Ozcan-Kucuk*, Bilal Ege, Mahmut Koparal, Ataman Gonel and Ismail Koyuncu

Volume 24 , Issue 2 , 2021

Published on: 29 July, 2020

Page: [286 - 293] Pages: 8

DOI: 10.2174/1386207323999200729114410

Price: $65

Abstract

Aim and Objective: Sleep bruxism is a complicated disease, and its cause remains controversial. If the etiology of bruxism is resolved, the treatment can be adjusted to the prevailing aetiological factor. Thus, the aim of this study was to evaluate the oxidative stress level and serum prolidase activity in patients with sleep bruxism.

Materials and Methods: Seventy healthy subjects and 51 patients with sleep bruxism were included in this study, and blood samples from all patients were collected. Serum samples were analyzed for total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and prolidase activity.

Results: The prolidase, TOS, and OSI levels were significantly higher in patients with bruxism than in the healthy controls (p = 0.001, p = 0.001, p = 0.001, respectively). The TAS level was significantly lower in bruxism patients than in healthy controls (p = 0.003).

Conclusion: The increased TOS, OSI, and prolidase levels and decreased TAS levels could be assumed to result in oxidative injury in patients with sleep bruxism. However, the study could not determine whether oxidative imbalance and increased serum prolidase levels could be a cause or a result of bruxism.

Keywords: Bruxism, prolidase activity, oxidative stress, antioxidant, oxidant system, oxidative status.

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