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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Immunoglobulin VH Domains and Beyond Design and Selection of Single-Domain Binding and Targeting Reagents

Author(s): S. D. Nuttall, R. A. Iring and P. J. Hudson

Volume 1 , Issue 3 , 2000

Page: [253 - 263] Pages: 11

DOI: 10.2174/1389201003378906

Price: $65

Abstract

Identification of the smallest antibody fragment still capable of binding to antigen has progressed from full antibody molecules to Fab and recombinant single chain Fv fragments. Now, a further reduction to single domain binding proteins based upon immunoglobulin VH and VH-like domains offers exciting prospects in the development of novel immunotherapeutics and immunodiagnostics. Minimisation of the antigen-binding fragment to such small single-domain proteins offers the advantages of enhanced stability, and possibly access to a class of antigenic epitopes not generally recognised by conventional antibodies.

Keywords: Immunoglobulin VH Domains, Fv fragments, Recombinant single chain, Natural VH Domains, Camelidae, Camelisation


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