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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

General Research Article

Possible Involvement of N-methyl-D-aspartate Receptor (NMDA-R) in the Antidepressant- like Effect of Trigonelline in Male Mice

Author(s): Maryam Anjomshoa, Shakiba N. Boroujeni, Esmaeel Bagheri, Zahra Lorigooini and Hossein Amini-Khoei*

Volume 26 , Issue 39 , 2020

Page: [5067 - 5071] Pages: 5

DOI: 10.2174/1381612826666200610181259

Price: $65

Abstract

Background and Aim: Depression is a mood disorder with high global prevalence. Depression is associated with a reduction in the hippocampal volume and change in its neurotransmitters function. Trigonelline is an alkaloid with neuroprotective activity. The aim of this study was to investigate the possible role of N-methyl-Daspartate (NMDA) receptor in the antidepressant-like effect of trigonelline, considering histopathological modifications of the hippocampus.

Methods: 60 Naval Medical Research Institute (NMRI) male mice were divided into 6 groups including group 1 (normal saline), groups 2, 3 and 4 (trigonelline at doses of 10, 50 and 100 mg/kg), group 5 (effective dose of trigonelline plus NMDA agonist) and group 6 (sub-effective dose of trigonelline plus NMDA antagonist). Forced swimming test (FST) was used to assess depressive-like behavior. Hippocampi were separated under deep anesthesia and used for histopathological evaluation as well as NMDA receptor gene expression assessment.

Results: Trigonelline at doses of 10, 50 and 100 significantly reduced the immobility time in the FST in comparison to the control group. The administration of the sub-effective dose of trigonelline plus ketamine (an NMDA receptor antagonist) potentiated the effect of the sub-effective dose of trigonelline. In addition, co-treatment of an effective dose of trigonelline with NMDA mitigated the antidepressant-like effect of trigonelline. Trigonelline at doses of 50 and 100 mg/kg significantly increased the diameter of the CA1 area of the hippocampus.

Conclusion: Trigonelline showed an antidepressant-like effect in mice, probably via attenuation of NMDA receptor activity and an increase in the CA1 region of the hippocampus.

Keywords: Depression, NMDA receptor, hippocampus, trigonelline, mice, Naval Medical Research Institute (NMRI).

[1]
Sanmukhani J, Satodia V, Trivedi J, et al. Efficacy and safety of curcumin in major depressive disorder: A randomized controlled trial. Phytother Res 2014; 28(4): 579-85.
[http://dx.doi.org/10.1002/ptr.5025] [PMID: 23832433]
[2]
Rabiei Z, Rabiei S. A review on antidepressant effect of medicinal plants. Bangladesh J Pharmacol 2017; 12(1): 1-11.
[http://dx.doi.org/10.3329/bjp.v12i1.29184]
[3]
Mervaala E, Föhr J, Könönen M, et al. Quantitative MRI of the hippocampus and amygdala in severe depression. Psychol Med 2000; 30(1): 117-25.
[http://dx.doi.org/10.1017/S0033291799001567] [PMID: 10722182]
[4]
Cobb JA, Simpson J, Mahajan GJ, et al. Hippocampal volume and total cell numbers in major depressive disorder. J Psychiatr Res 2013; 47(3): 299-306.
[http://dx.doi.org/10.1016/j.jpsychires.2012.10.020] [PMID: 23201228]
[5]
Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS. Hippocampal volume reduction in major depression. Am J Psychiatry 2000; 157(1): 115-8.
[http://dx.doi.org/10.1176/ajp.157.1.115] [PMID: 10618023]
[6]
Sapolsky RM. The possibility of neurotoxicity in the hippocampus in major depression: A primer on neuron death. Biol Psychiatry 2000; 48(8): 755-65.
[http://dx.doi.org/10.1016/S0006-3223(00)00971-9] [PMID: 11063972]
[7]
Amsterdam JD, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB. Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. Altern Ther Health Med 2012; 18(5): 44-9.
[PMID: 22894890]
[8]
Kuhn MA, Winston D. Herbal therapy and supplements: A scientific and traditional approach. Lippincott Williams & Wilkins 2000.
[9]
Omidi-Ardali H, Lorigooini Z, Soltani A, Balali-Dehkordi S, Amini-Khoei H. Inflammatory responses bridge comorbid cardiac disorder in experimental model of IBD induced by DSS: protective effect of the trigonelline. Inflammopharmacology 2019; 27(6): 1265-73.
[http://dx.doi.org/10.1007/s10787-019-00581-w] [PMID: 30924005]
[10]
Khalili M, Alavi M, Esmaeil-Jamaat E, Baluchnejadmojarad T, Roghani M. Trigonelline mitigates lipopolysaccharide-induced learning and memory impairment in the rat due to its anti-oxidative and anti-inflammatory effect. Int Immunopharmacol 2018; 61: 355-62.
[http://dx.doi.org/10.1016/j.intimp.2018.06.019] [PMID: 29935483]
[11]
Jeong Y-I, Kim DH, Chung KD, Kim YH, Lee YS, Choi K-C. Antitumor activity of trigonelline-incorporated chitosan nanoparticles. J Nanosci Nanotechnol 2014; 14(8): 5633-7.
[http://dx.doi.org/10.1166/jnn.2014.8818] [PMID: 25935980]
[12]
Arai K, Terashima H, Aizawa S, et al. Simultaneous determination of trigonelline, caffeine, chlorogenic acid and their related compounds in instant coffee samples by HPLC using an acidic mobile phase containing octanesulfonate. Anal Sci 2015; 31(8): 831-5.
[http://dx.doi.org/10.2116/analsci.31.831] [PMID: 26256608]
[13]
Antonisamy P, Arasu MV, Dhanasekaran M, et al. Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms. Food Funct 2016; 7(1): 398-408.
[http://dx.doi.org/10.1039/C5FO00403A] [PMID: 26499137]
[14]
Zhou J, Zhou S, Zeng S. Experimental diabetes treated with trigonelline: effect on β cell and pancreatic oxidative parameters. Fundam Clin Pharmacol 2013; 27(3): 279-87.
[http://dx.doi.org/10.1111/j.1472-8206.2011.01022.x] [PMID: 22172053]
[15]
Zhou J, Chan L, Zhou S. Trigonelline: A plant alkaloid with therapeutic potential for diabetes and central nervous system disease. Curr Med Chem 2012; 19(21): 3523-31.
[http://dx.doi.org/10.2174/092986712801323171] [PMID: 22680628]
[16]
Mirzaie M, Khalili M, Kiasalari Z, Roghani M. Neuroprotective and antiapoptotic potential of trigonelline in a striatal 6-hydroxydopamine rat model of Parkinson’s disease. Neurophysiology 2016; 48(3): 176-83.
[http://dx.doi.org/10.1007/s11062-016-9586-6]
[17]
Lee HK, Kameyama K, Huganir RL, Bear MF. NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 1998; 21(5): 1151-62.
[http://dx.doi.org/10.1016/S0896-6273(00)80632-7] [PMID: 9856470]
[18]
Zarate CA Jr, Du J, Quiroz J, et al. Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system. Ann N Y Acad Sci 2003; 1003(1): 273-91.
[http://dx.doi.org/10.1196/annals.1300.017] [PMID: 14684452]
[19]
Monaghan DT, Cotman CW. Distribution of N-methyl-D-aspartate-sensitive L-[3H] glutamate-binding sites in rat brain. J Neurosci 1985; 5(11): 2909-19.
[http://dx.doi.org/10.1523/JNEUROSCI.05-11-02909.1985] [PMID: 2865341]
[20]
Li N, Lee B, Liu R-J, et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 2010; 329(5994): 959-64.
[http://dx.doi.org/10.1126/science.1190287] [PMID: 20724638]
[21]
Haj-Mirzaian A, Amiri S, Amini-Khoei H, et al. Involvement of NO/NMDA-R pathway in the behavioral despair induced by amphetamine withdrawal. Brain Res Bull 2018; 139: 81-90.
[http://dx.doi.org/10.1016/j.brainresbull.2018.02.001] [PMID: 29421244]
[22]
Rogóz Z, Skuza G, Maj J, Danysz W. Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats. Neuropharmacology 2002; 42(8): 1024-30.
[http://dx.doi.org/10.1016/S0028-3908(02)00055-2] [PMID: 12128003]
[23]
Berman RM, Cappiello A, Anand A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 2000; 47(4): 351-4.
[http://dx.doi.org/10.1016/S0006-3223(99)00230-9] [PMID: 10686270]
[24]
Kos T, Popik P. A comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist, memantine, in mice. Behav Pharmacol 2005; 16(3): 155-61.
[http://dx.doi.org/10.1097/00008877-200505000-00004] [PMID: 15864070]
[25]
Amiri S, Alijanpour S, Tirgar F, et al. NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice. Neuroscience 2016; 329: 122-33.
[http://dx.doi.org/10.1016/j.neuroscience.2016.05.003] [PMID: 27167081]
[26]
Lorigooini Z, Salimi N, Soltani A, Amini-Khoei H. Implication of NMDA-NO pathway in the antidepressant-like effect of ellagic acid in male mice. Neuropeptides 2019.76101928
[http://dx.doi.org/10.1016/j.npep.2019.04.003] [PMID: 31078318]
[27]
Nouri A, Hashemzadeh F, Soltani A, Saghaei E, Amini-Khoei H. Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress. Pharm Biol 2020; 58(1): 64-71.
[http://dx.doi.org/10.1080/13880209.2019.1702704] [PMID: 31873049]
[28]
Schoenfeld TJ, McCausland HC, Morris HD, Padmanaban V, Cameron HA. Stress and loss of adult neurogenesis differentially reduce hippocampal volume. Biol Psychiatry 2017; 82(12): 914-23.
[http://dx.doi.org/10.1016/j.biopsych.2017.05.013] [PMID: 28629541]
[29]
Erfani S, Aboutaleb N, Oryan S, et al. Visfatin inhibits apoptosis and necrosis of hippocampus CA3 cells following transient global ischemia/reperfusion in rats. Int J Pept Res Ther 2015; 21(2): 223-8.
[http://dx.doi.org/10.1007/s10989-014-9449-1]
[30]
Shahraki FH, Namjoo AR, Pirbalout AG, Lorigooini Z, Rafieian-Kopaei M, Arjenaki MG. Antidepressant-like effect of Lavandula angustifolia Mill and Citrus aurantium Duh essential oils with forced swimming test in reserpinized mice balb/c. Razi J Med Sci 2017; 23(151)
[31]
Rabiei Z, Movahedi E, Rafieian-Kopaei M, Lorigooini Z. Antidepressant effects of Trifolium pratense hydroalcholic extract in mice. Indian J Physiol Pharmacol 2016; 2(1): 33-24.
[32]
Dang H, Chen Y, Liu X, et al. Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33(8): 1417-24.
[http://dx.doi.org/10.1016/j.pnpbp.2009.07.020] [PMID: 19632285]
[33]
Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan JF, Dinan TG. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 2010; 170(4): 1179-88.
[http://dx.doi.org/10.1016/j.neuroscience.2010.08.005] [PMID: 20696216]
[34]
Lorigooini Z, Sadeghi Dehsahraei K, Bijad E, Habibian Dehkordi S, Amini-Khoei H. Trigonelline through the attenuation of oxidative stress exerts antidepressant- and anxiolytic-like effects in a mouse model of maternal separation stress. Pharmacology 2020; 105(5-6): 289-99.
[http://dx.doi.org/10.1159/000503728] [PMID: 31630147]
[35]
Assad T, Khan RA. Effect of methanol extract of Trigonella foenum-graecum L. seeds on anxiety, sedation and motor coordination. Metab Brain Dis 2017; 32(2): 343-9.
[http://dx.doi.org/10.1007/s11011-016-9914-y] [PMID: 27639708]
[36]
Farber NB. NMDA Antagonists for Treatment-Resistant Depression 2018.
[http://dx.doi.org/10.1007/164_2018_165]
[37]
Pochwat B, Nowak G, Szewczyk B. An update on NMDA antagonists in depression. Expert Rev Neurother 2019; 19(11): 1055-67.
[http://dx.doi.org/10.1080/14737175.2019.1643237] [PMID: 31328587]
[38]
Lavretsky H, Laird KT, Krause-Sorio B, et al. A randomized double-blind placebo-controlled trial of combined escitalopram and memantine for older adults with major depression and subjective memory complaints. Am J Geriatr Psychiatry 2020; 28(2): 178-90.
[PMID: 31519517]
[39]
Duman RS. Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide. F1000 Res 2018; 7: 7.
[http://dx.doi.org/10.12688/f1000research.14344.1] [PMID: 29899972]
[40]
Kavalali ET, Monteggia LM. How does ketamine elicit a rapid antidepressant response? Curr Opin Pharmacol 2015; 20: 35-9.
[http://dx.doi.org/10.1016/j.coph.2014.11.005] [PMID: 25462290]
[41]
Sheline YI, Liston C, McEwen BS. Parsing the hippocampus in depression: Chronic stress, hippocampal volume, and major depressive disorder. Biol Psychiatry 2019; 85(6): 436-8.
[http://dx.doi.org/10.1016/j.biopsych.2019.01.011] [PMID: 30777168]
[42]
McKinnon MC, Yucel K, Nazarov A, MacQueen GM. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 2009; 34(1): 41-54.
[PMID: 19125212]
[43]
Cole J, Costafreda SG, McGuffin P, Fu CH. Hippocampal atrophy in first episode depression: A meta-analysis of magnetic resonance imaging studies. J Affect Disord 2011; 134(1-3): 483-7.
[http://dx.doi.org/10.1016/j.jad.2011.05.057] [PMID: 21745692]
[44]
Shimizu E, Hashimoto K, Okamura N, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003; 54(1): 70-5.
[http://dx.doi.org/10.1016/S0006-3223(03)00181-1] [PMID: 12842310]
[45]
Zhou JY, Zhou SW. Protection of trigonelline on experimental diabetic peripheral neuropathy. Evidence-based Complementary Alter Med 2012.
[http://dx.doi.org/10.1155/2012/164219]
[46]
Chowdhury AA, Gawali NB, Munshi R, Juvekar AR. Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice. Metab Brain Dis 2018; 33(3): 681-91.
[http://dx.doi.org/10.1007/s11011-017-0147-5] [PMID: 29277879 ]

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