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Current Analytical Chemistry

Editor-in-Chief

ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

Research Article

A Novel Electrochemical Sensor Based on Au-rGO Nanocomposite Decorated with Poly(L-cysteine) for Determination of Paracetamol

Author(s): Lin Zhang, Xiaojing Si, Xiaoxia Yan, Haibo He*, Dongmei Deng and Liqiang Luo*

Volume 16 , Issue 8 , 2020

Page: [1063 - 1070] Pages: 8

DOI: 10.2174/1573411016999200414145325

Price: $65

Abstract

Background: Paracetamol is a common antipyretic and analgesic drug, but its excessive intake can accumulate toxic metabolites and cause kidney and liver damage, so it is critical to determine the content of paracetamol for clinical diagnosis and dose use.

Methods: Au-reduced graphene oxide (Au-rGO) nanocomposite decorated with poly(L-cysteine) on carbon paste electrode was fabricated for the determination of paracetamol. Au-rGO was first coelectrodeposited on the carbon paste electrode surface. Afterwards, L-cysteine was electropolymerized to fabricate the Au-rGO/poly(L-cysteine) modified carbon paste electrode. Scanning electron microscope was used to characterize the morphology of Au-rGO and poly(L-cysteine)/Au-rGO. The electrochemical properties of the sensor were studied by cyclic voltammetry and differential pulse voltammetry.

Results: After exploring the optimal conditions, the sensor showed a wide linear response for paracetamol detection in the range of 1-200 μM with a detection limit of 0.5 μM (S/N = 3).

Conclusion: The fabricated sensor demonstrated good sensitivity with rapid detection capacity in real samples.

Keywords: Au-rGO, carbon paste electrode, electrochemical sensor, L-cysteine, paracetamol, scanning electron microscope.

Graphical Abstract
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