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Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Research Article

Isolation of Morganella Morganii and Providencia Species from Clinical Samples in a Tertiary Care Hospital in North India

Author(s): Shiwani Sharma, Prapti Bora, Nidhi Singla*, Varsha Gupta and Jagdish Chander

Volume 21 , Issue 1 , 2021

Published on: 28 January, 2020

Page: [84 - 89] Pages: 6

DOI: 10.2174/1871526520666200128162646

Price: $65


Introduction: The members of the tribe Proteeae, Morganella and Providencia are being increasingly recognized as important pathogens. The spectrum of disease caused by them is wide and in reported cases, the mortality is high. Previously both of these pathogens were considered to be rare pathogens as the potential to cause nosocomial transmission and infection was not much studied. But their phenomenal evolution and increase in multidrug-resistance (MDR) strains of these pathogens are posing a major threat toward public health throughout the world.

Methods: This present study was carried out from July 2018 to December 2018 on all the pus and body fluid samples that were received in the Department of Microbiology. Samples were processed as per the standard Microbiological guidelines and also were analyzed for their antimicrobial susceptibility profile as per Clinical Laboratory Standards Institute.

Results: Out of 8425 samples received, 2140 were culture positive, amongst which 19 samples (0.89%) were positive for Providencia species (9) and Morganella morganii(10). The male : female ratio of these 19 patients was 2.8 : 1 and maximum patients (13) belonged to 20-60 years. As far as risk factors are concerned, maximum patients were diabetics (7) followed by abnormal liver function tests (6), concomitant UTI (6), history of invasive procedure (5), prior exposure to antibiotics (5) and urinary catheterization (4). About 6 were polymicrobial infections. Antibiotic susceptibility patterns revealed that Providencia strains were sensitive to ampicillin- sulbactum (77.7%) and amikacin (77.7%), while all Morganella strains were 100% sensitive to tobramycin and piperacillintazobactam.

Conclusion: This study heralds in need for more research in this area as infections caused by these two pathogens are on the rise. Moreover, resistance to antimicrobials is also an increasingly common problem thus delaying the treatment and prognosis of the disease.

Keywords: Morganella, North India, Providencia, incidence, pathogens, resistance.

Graphical Abstract
Abdallah, M.; Balshi, A. First literature review of carbapenem-resistant Providencia. New Microbes New Infect., 2018, 25, 16-23.
[ ] [PMID: 29983987]
Ghosh, S.; LaPara, T.M. The effects of subtherapeutic antibiotic use in farm animals on the proliferation and persistence of antibiotic resistance among soil bacteria. ISME J., 2007, 1(3), 191-203.
[ ] [PMID: 18043630]
Seija, V.; Medina Presentado, J.C.; Bado, I.; Papa Ezdra, R.; Batista, N.; Gutierrez, C.; Guirado, M.; Vidal, M.; Nin, M.; Vignoli, R. Sepsis caused by New Delhi metallo-β-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review. Int. J. Infect. Dis., 2015, 30, 20-26.
[ ] [PMID: 25447717]
Magiorakos, A.P.; Srinivasan, A.; Carey, R.B.; Carmeli, Y.; Falagas, M.E.; Giske, C.G.; Harbarth, S.; Hindler, J.F.; Kahlmeter, G.; Olsson-Liljequist, B.; Paterson, D.L.; Rice, L.B.; Stelling, J.; Struelens, M.J.; Vatopoulos, A.; Weber, J.T.; Monnet, D.L. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin. Microbiol. Infect., 2012, 18(3), 268-281.
[ ] [PMID: 21793988]
Krake, P.R.; Tandon, N. Infective endocarditis due to Providenca stuartii. South. Med. J., 2004, 97(10), 1022-1023.
[ ] [PMID: 15558939]
Simon, C.; Dieli, M.; Brucato, A.; Pedrotti, P.; Brambilla, P.; Curri, S.F.; Senni, M.; Pericotti, S.; Suter, F.; Ferrazzi, P. Images in cardiovascular medicine. Bacterial pericarditis due to Providencia stuartii: an atypical case of relapsing pericarditis. Circulation, 2010, 122(4), e401-e403.
[ ] [PMID: 20660810]
Unverdi, S.; Akay, H.; Ceri, M.; Inal, S.; Altay, M.; Demiroz, A.P.; Duranay, M. Peritonitis due to Providencia stuartii. Perit. Dial. Int., 2011, 31(2), 216-217.
[PMID: 21427258]
Sipahi, O.R.; Bardak-Ozcem, S.; Ozgiray, E.; Aydemir, S.; Yurtseven, T.; Yamazhan, T.; Tasbakan, M.; Ulusoy, S. Meningitis due to Providencia stuartii. J. Clin. Microbiol., 2010, 48(12), 4667-4668.
[ ] [PMID: 20980575]
Wie, S.H. Clinical significance of Providencia bacteremia or bacteriuria. Korean J. Intern. Med., 2015, 30(2), 167-169.
Hayakawa, K.; Marchaim, D.; Divine, G.W.; Pogue, J.M.; Kumar, S.; Lephart, P.; Risko, K.; Sobel, J.D.; Kaye, K.S. Growing prevalence of Providencia stuartii associated with the increased usage of colistin at a tertiary health care center. Int. J. Infect. Dis., 2012, 16(9), e646-e648.
[ ] [PMID: 22818111]
Perween, N.; Bharara, T.; Krishanprakash, S. Bacteriological profile of pus and body fluid isolates and their antimicrobial susceptibility pattern. J Bacteriol Mycol., 2018, 5(1), 1060.
Bhargava, D.; Kar, S.; Saha, M. Prevalence of non-fermentative gram negative bacilli infection in tertiary care hospital in birgunj. Nepal. Int. J. Curr. Microbiol. Appl. Sci., 2015, 4(7), 301-307.
Liu, H.; Zhu, J.; Hu, Q.; Rao, X. Morganella morganii, a non-negligent opportunistic pathogen. Int. J. Infect. Dis., 2016, 50, 10-17.
[ ] [PMID: 27421818]
Toleman, M.A.; Walsh, T.R. Combinatorial events of insertion sequences and ICE in Gram-negative bacteria. FEMS Microbiol. Rev., 2011, 35(5), 912-935.
[ ] [PMID: 21729108]
Rojas, L.; Vinuesa, T.; Tubau, F.; Truchero, C.; Benz, R.; Viñas, M. Integron presence in a multiresistant Morganella morganii isolate. Int. J. Antimicrob. Agents, 2006, 27(6), 505-512.
[ ] [PMID: 16690260]
Tucci, V.; Isenberg, H.D. Hospital cluster epidemic with Morganella morganii. J. Clin. Microbiol., 1981, 14(5), 563-566.
[ ] [PMID: 7309851]
Isobe, H.; Motomura, K.; Kotou, K.; Sakai, H.; Satoh, M.; Nawata, H. Spontaneous bacterial empyema and peritonitis caused by Morganella morganii. J. Clin. Gastroenterol., 1994, 18(1), 87-88.
[ ] [PMID: 8113596]
Samonis, G.; Anatoliotaki, M.; Apostolakou, H.; Souglakos, J.; Georgoulias, V. Fatal septicemia and meningitis due to Morganella morganii in a patient with Hodgkin’s disease. Scand. J. Infect. Dis., 2001, 33(7), 553-555.
[ ] [PMID: 11515771]
Matsuo, H.; Ishibashi, T.; Araki, C.; Sakamaki, H.; Mazume, H.; Ueki, Y.; Miyake, S.; Tominaga, Y.; Toyomura, K. Report of three cases of purple urine bag syndrome which occurred with a combination of both E. coli and M. morganii. Kansenshogaku Zasshi, 1993, 67(5), 487-490.
[ ] [PMID: 8320467]
Koyuncu, Ş.; Ozan, F. Morganella morganii osteomyelitis complicated by secondary septic knee arthritis: a case report. Acta Orthop. Traumatol. Turc., 2012, 46(6), 464-467.
[ ] [PMID: 23428772]
Lee, I.K.; Liu, J.W. Clinical characteristics and risk factors for mortality in Morganella morganii bacteremia. J. Microbiol. Immunol. Infect., 2006, 39(4), 328-334.
[PMID: 16926980]
Singla, N.; Kaistha, N.; Gulati, N.; Chander, J. Morganella morganii could be an important intensive care unit pathogen. Ind. J. Crit. Care Med., 2010, 14(3), 154-5.
Falagas, M.E.; Kavvadia, P.K.; Mantadakis, E.; Kofteridis, D.P.; Bliziotis, I.A.; Saloustros, E.; Maraki, S.; Samonis, G. Morganella morganii infections in a general tertiary hospital. Infection, 2006, 34(6), 315-321.
[ ] [PMID: 17180585]
Choi, H.K.; Kim, Y.K.; Kim, H.Y.; Park, J.E.; Uh, Y. Clinical and microbiological features of Providencia bacteremia: experience at a tertiary care hospital. Korean J. Intern. Med. , 2015, 30(2), 219-225.
[ ] [PMID: 25750564]

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