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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Nanostructured Modulators of Neuroglia

Author(s): Dusica Maysinger* and Jeff Ji

Volume 25 , Issue 37 , 2019

Page: [3905 - 3916] Pages: 12

DOI: 10.2174/1381612825666190912163339

Price: $65


Biological and synthetic nanostructures can influence both glia and neurons in the central nervous system. Neurons represent only a small proportion (about 10%) of cells in the brain, whereas glial cells are the most abundant cell type. Non-targeted nanomedicines are mainly internalized by glia, in particular microglia, and to a lesser extent by astrocytes. Internalized nanomedicines by glia indirectly modify the functional status of neurons. The mechanisms of biochemical, morphological and functional changes of neural cells exposed to nanomedicines are still not well-understood. This minireview provides a cross-section of morphological and biochemical changes in glial cells and neurons exposed to different classes of hard and soft nanostructures.

Keywords: Microglia, astrocytes, neurons, nanoparticles, gold nanoparticles, dendritic polyglycerols, lysosomes, confocal microscopy, organotypic cultures.

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