The Multi-Organ Donor: A Guide to Selection, Preservation and Procurement
Editor(s): Robert S.D. Higgins and Juan A. Sanchez
DOI: 10.2174/97816810875661180301eISBN: 978-1-68108-756-6, 2018ISBN: 978-1-68108-757-3ISSN: 2589-174X (Print)ISSN: 2589-1758 (Online)
Advances in the science of immunology have improved the success rate of organ transplantations since the mid twentieth century. Organ transplantation is now a lifesaving medical procedure for thousands of patients around the world with end-organ diseases. The lifesaving potential of transplantation has been limited by the number and quality of appropriate organ donors. The evolution of brain death criteria by the Harvard Ad-Hoc Committee Report has opened the door to understanding the importance of medical, legal and ethical challenges of organ donation in support of the growth of the transplant science. The possibility of organ donation from living donors has enhanced organ availability for patients with kidney failure. Modern inotropes and immunosuppression regimens have been critical to the success of other organ transplant procedures. However, the cornerstone of successful transplantation continues to be the appropriate selection, evaluation, preservation of organ tissues and the successful surgical procurement process to mitigate the impact of tissue ischemia and reperfusion.
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