Optimization and Characterization of Biogenic Silver Nanoparticles Synthesized by Leaves Extract of Alphonsea Madraspatana

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Author(s): Amita Sahu, Sudhanshu Shekhar Swain, Goutam Ghosh, Deepak Pradhan, Dipak Kumar Sahu, Prativa Biswasroy, Goutam Rath*

Journal Name: Current Bioactive Compounds

Abstract:

Background: Literature evidences as well as traditional uses of genus Alphonsea reveal significant antimicrobial and anti-oxidant activity, which encourages to consider A. madraspatana to have potent antimicrobials, there by offering potential adjuncts to synthesize improved antimicrobial Silver nanoparticles (AgNPs). The objective of the present exposition is to optimize reaction parameters to synthesize antimicrobial Biogenic Silver nanoparticles (BAgNPs) from extract of A. madraspatana leaves (AML) and to evaluate the effect against bacteria.

Methods: BAgNPs was synthesized by optimized reaction. The Synthesized nanoparticles were characterized by UV, IR, ICP-MS and XRD analysis. The antibacterial potency of optimized BAgNPs was evaluated against E. coli by comparing with positive controls.

Results: Results of optimization process indicate nanoscale BAgNPs were produced at operating temp. of 45°C for 120 min at pH 8 with 1:5 volume ratio of AgNO3 and extract. Optimized BAgNPs exhibits relatively higher antimicrobial activity (31±1mm) compared to Ciprofloxacin (27±1mm) and marketed nano silver (28± 2 mm). The developed BAgNPs shows comparable biofilm inhibition (86.50%) as compared to marketed nano silver (88.10%) and Ciprofloxacin (83.10%).

Conclusion: Experimental evidence suggests methanolic extract of AML under predefined conditions successfully generate nano-template of silver with better antibacterial response against E. coli.

Keywords: A. madraspatana, Silver nanoparticles, Optimization, E. coli, Antibiofilm activity.

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DOI: 10.2174/1573407217666210223092824
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Meet Our Section Editor

Author(s): Inamuddin

Journal Name: Recent Innovations in Chemical Engineering
Formerly Recent Patents on Chemical Engineering

Volume 14 , Issue 2 , 2021

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VOLUME: 14
ISSUE: 2
Year: 2021
Page: [103 - 103]
Pages: 1
DOI: 10.2174/240552041402210223090359


Recent Innovations in Chemical Engineering

Formerly Recent Patents on Chemical Engineering

Editor-in-Chief:

Yousheng Tao
Haixi Institutes,

Chinese Academy of Sciences
Fuzhou
China

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Current Perspectives of Healthy Mitochondrial Function for Healthy Neurons

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Author(s): Arunachalam Muthuraman*, Muthusamy Ramesh*, Venkataratinakumar Thiagarajan, Sumeet Kumar Singla, Seema Mudhol, Serva Peddha Muthukumar

Journal Name: Current Drug Targets

Abstract:

The neuron is high energy utilizing tissue. The rate of neuronal cell respiration is higher than in other cells. The cellular respiration occurs with mitochondria. Healthy production and functions of mitochondria play a key role in the maintenances of healthy neurons. In pathological conditions such as neurodegenerative diseases, healthy mitochondria help to alleviate pathological events in neuronal cells. Conversely, mitochondrial dysfunction promotes the acceleration of the neurodegenerative process. Furthermore, glial-derived mitochondria contribute to multiple roles in the regulation of healthy neuron functions. It also supports releasing of the neurotransmitters; generation of the impulses, regulation of the membrane potential and molecular dynamics; controlling of the axonal transport; controlling of the mitochondrial fission and fusion functions in the peripheral as well as the central nervous system. Moreover, it plays a key role in the regeneration process of neuronal cells. Therefore, healthy mitochondria can provide a healthy environment for neuronal cell function and can treat neurodegenerative disorders. In this review, we explore the current view of healthy mitochondria and their role in healthy neuronal functions.

Keywords: Glial cell, membrane potential, mitochondrial fusion, mitochondrial fission, neurodegenerative disorder, neurotransmitter.

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DOI: 10.2174/1389450122666210222163528
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Reducing contact resistance of carbon nanotubes by doping nickel nanoparticles

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Author(s): Zhiqi Liang, Shuai Dong, Chunrui Chang, Zhiming Zhang, Libao An*

Journal Name: Current Nanoscience

Abstract:

Background: In micro- and nano-electronic devices, there is often a high contact resistance between carbon nanotubes (CNTs) and metals, which leads to the heating of electronic devices and the loss of a large amount of energy. Doping will be used to improve the electrical contact performance between CNTs and metals.

Significance: A simple and low-cost electroless deposition technique is used to prepare nickel-doped carbon nanotubes (CNT-Ni) under different doping conditions, and to explore the influence of different nickel (Ni) doped samples on the electrical contact properties of CNTs.

Method: In this study, the transition metal Ni was chosen to prepare CNT-Ni by electroless deposition method using nickel chloride hexahydrate (NiCl2•6H2O) as medium. The morphology and structure of treated CNTs were characterized through scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Raman spectrometer and ultraviolet photoelectron spectrometer (UPS). The contact resistance between CNTs and metals was measured by inductance capacitance resistance (LCR) tester.

Result: The morphological characterization results showed that the incorporated Ni nanoparticles had moderate particle size and good combination with CNTs. The structural characterization indicated that the core component of the doped nanoparticles was transition metal element Ni, and the doping type was P-type, with the significantly increased work function of the doped CNTs. And the average value of the contact resistance between the Ni-doped CNTs and the gold electrode decreased by nearly 71.63%.

Conclusion: This doping method can be used to effectively reduce the contact resistance between CNTs and metals. The research on the preparation and resistance reduction about CNT-Ni is of practical significance in reducing the heating of electronic devices in practical use and then improving the performance and service life of devices.

Keywords: carbon nanotubes, electroless deposition, nickel nanoparticles, contact resistance

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DOI: 10.2174/1573413717666210222162943
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The effect of pre-operative autologous blood donation on bone marrow hematopoietic functions in rabbits after hepatectomy

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Author(s): Xiao-Fang Zhou, Yang Liu, Jia-Ming Xu, Jin-Huo Wang, Zhen-Zhou Li, Xun Zhou, Jian-Rong Guo*

Journal Name: Current Pharmaceutical Biotechnology

Abstract:

Background: Pre-operative autologous blood donation (PABD) is one of the most widely distributed autologous blood donation means, which has positive effect on erythropoiesis. However, whether PABD can stimulate the bone marrow hematopoiesis after hepatectomy have not been reported.

Methods: Totally 80 New Zealand rabbits were randomly divided into 4 groups that included control group, surgery group, hemodilutional autotransfusion (HA) group and PABD group. Automatic reticulocyte examination was performed to detect the content of reticulocyte and immature reticulocyte fractions (IRF). Flow cytometric analysis was employed to monitor the level of CD34+ cells and the cell cycle status. Southern blotting was conducted to determine the telomere length of CD34+ cells.

Results: The content of high fluorescence reticulocytes (HFR) and IRF was decreased at 6 h and 24 h after autotransfusion. However, the level of CD34+ cells was upregulated after PABD. Cell cycle status analysis revealed that majority of the CD34+ cells in HA and PABD group were maintained in G0/G1 phase. The telomere length in HA and PABD group was shorten than that of control group and surgery group.

Conclusion: PABD could promote the bone marrow hematopoietic functions in rabbits after hepatectomy via stimulating proliferation of CD34+ cells and shortening the telomere length of CD34+ cells, but the content of HFR was not increased immediately because of the stuck of CD34+ cells in G0/G1 phase.

Keywords: blood transfusion, PABD, hepatectomy, bone marrow hematopoiesis, autotransfusion, high fluorescence reticulocytes

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DOI: 10.2174/1389201022666210222162311
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Asafoetida, a Natural Medicine for a Future

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Author(s): Mohamad Hesam Shahrajabian, Wenli Sun, Qi Cheng*

Journal Name: Current Nutrition & Food Science

Abstract:

Background: Asafoetida is dried latex which is extracted from the taproot of many species of Ferula, a perennial herb native to the East Mediterranean and Central Asian regions. It is also a common ingredient in some cuisines.

Objective: The goal of this manuscript is survey on medicinal values and natural benefits of Asafoetida.

Methods: A literature search was conducted in Science Direct, Google, Google Scholar, PubMed, Wiley Online Library, Springer and Medline.

Results: The most important health benefits consist of reducing bloating, helping to relieve asthma, lower blood pressure and menstrual pain, as well as treating headaches, insect bites, indigestion, and as a laxative. It is good for diabetic people, treats nerve disorders, helps fight free radicals, aids in reducing acne, treats corns and calluses, and reduces hair loss.

Conclusion: This review article allowed verifying Asafoetida as sources of compounds with valuable nutritional and bioactive properties with great ability for incorporation into foods with functional properties.

Keywords: Medicinal plant, Health benefits, Asthma, Anticancer, Headaches, Natural products

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DOI: 10.2174/1573401317666210222161609
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Predicting Protein Surface Property with its Surface Hydrophobicity

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Author(s): Sen Tang, Junsheng Li*, Guoxia Huang, Liujuan Yan

Journal Name: Protein & Peptide Letters

Abstract:

This article reviews and discusses the relationship between surface hydrophobicity and other surface properties of proteins and the possibility of using surface hydrophobicity as a key indicator to predict and evaluate the changes in the surface properties of a protein. Hydrophobicity is the main driving force of protein folding; it affects the structure and functions. Surface hydrophobicity and other surface properties of proteins are controlled by their spatial structures. Due to the hydrophobic interactions, most proteins fold into their globular structures, and they lack sufficient hydrophobic residues on the molecular surface; thus, they do not exhibit excellent surface properties. Surface hydrophobicity is closely related to the changes in the surface property of proteins because it directly reflects the actual distribution of the hydrophobic residues on the surface of a protein. The molecular structure of a protein can be changed or modified to remove the constraints of spatial structures and expose more hydrophobic residues on the molecular surface, which may improve the surface properties of proteins. Therefore, the changes in the surface hydrophobicity caused by changes in the molecular structure can be an ideal key indicator to predict and evaluate the changes in the surface properties of a protein.

Keywords: Prediction, evaluation, surface property, surface hydrophobicity, proteins, indicator.

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DOI: 10.2174/0929866528666210222160603
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Acknowledgements to Reviewers

Author(s):

Journal Name: MicroRNA

Volume 9 , Issue 5 , 2020

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VOLUME: 9
ISSUE: 5
Year: 2020
Published on: 22 February, 2021
Page: [395 - 395]
Pages: 1
DOI: 10.2174/221153660905210222160356



Meet Our Editorial Board Member

Author(s): Sercan Ergun

Journal Name: MicroRNA

Volume 9 , Issue 5 , 2020

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VOLUME: 9
ISSUE: 5
Year: 2020
Published on: 22 February, 2021
Page: [321 - 321]
Pages: 1
DOI: 10.2174/221153660905210222160245