Abstract
Lipid nanoparticles loading the sunscreen 2,4-dihydroxybenzophenone (DHB-LNPs) have been prepared by high-pressure homogenization and ultrasound techniques. The combination of both methodologies improves the entrapment efficiency percentage reaching 95%. The morphology of the DHB-LNPs was studied with scanning electron microscopy (SEM) and atomic force microscopy (AFM), while the surface and interior chemical composition was analyzed by X-ray photoelectron spectroscopy (XPS) at different irradiation times. Conductivity of aqueous dispersions of the DHBLNPs was determined by impedance spectroscopy. A possible DHB-LNPs application related to drug release in a system simulating skin-properties is shown.
Keywords: Lipid nanoparticles, 2, 4-dihydroxybenzophenone, homogenizer, ultrasounds, SEM, XPS, impedance spectroscopy, photoelectron, atomic force microscopy
Medicinal Chemistry
Title:Preparation, Chemical and Electrical Characterizations of Lipid Nanoparticles Loaded with Dihydroxybenzophenone
Volume: 8 Issue: 4
Author(s): Hierrezuelo Jesus, Benavente Juana, Lopez–Romero Juan Manuel, Martinez de Yuso Maria del Valle and Rodriguez–Castellon Enrique
Affiliation:
Keywords: Lipid nanoparticles, 2, 4-dihydroxybenzophenone, homogenizer, ultrasounds, SEM, XPS, impedance spectroscopy, photoelectron, atomic force microscopy
Abstract: Lipid nanoparticles loading the sunscreen 2,4-dihydroxybenzophenone (DHB-LNPs) have been prepared by high-pressure homogenization and ultrasound techniques. The combination of both methodologies improves the entrapment efficiency percentage reaching 95%. The morphology of the DHB-LNPs was studied with scanning electron microscopy (SEM) and atomic force microscopy (AFM), while the surface and interior chemical composition was analyzed by X-ray photoelectron spectroscopy (XPS) at different irradiation times. Conductivity of aqueous dispersions of the DHBLNPs was determined by impedance spectroscopy. A possible DHB-LNPs application related to drug release in a system simulating skin-properties is shown.
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Cite this article as:
Jesus Hierrezuelo, Juana Benavente, Juan Manuel Lopez–Romero, de Yuso Maria del Valle Martinez and Enrique Rodriguez–Castellon, Preparation, Chemical and Electrical Characterizations of Lipid Nanoparticles Loaded with Dihydroxybenzophenone, Medicinal Chemistry 2012; 8 (4) . https://dx.doi.org/10.2174/157340612801216238
DOI https://dx.doi.org/10.2174/157340612801216238 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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