Abstract
Ionizing radiation used for sterilization of drugs may lead to drug degradation and therefore essential element of the validation process is the choice of optimal conditions for sterilization, i.e. radiation dose and radiation source. This investigation examines and compares radiostability of derivatives of 1-phenylpropan-1-ol exposed to the same effective doses of ionizing radiation but emitted from different sources: gamma radiation (60Co) and high energy electrons emitted by linear electron accelerator. The drugs used in this investigation were chloramphenicol, its ester (chloramphenicol sodium succinate) and analog (thiamphenicol).
It was found that gamma radiation had a more destructive effect on drugs than high energy electrons. This was apparent from the change in the color intensity, increase in the concentration of free radicals, the number of radiolysis products and larger decrease in the drug content. The difference in the power between the two sources of ionizing radiation (1 kGy/h for 60Co and 10 kGy/s for high energy electrons) could account for that.
Keywords: EPR, radiation sterilization, radiodegradation, radiolytic yield, gamma radiation, electrons, ionizing radiation, chloramphenicol, radiostability, microbiological purity
Current Analytical Chemistry
Title:Comparison of Influence of Gamma Rays and E-beam on Some Chloramphenicol Derivatives
Volume: 8 Issue: 3
Author(s): B. Marciniec, M. Stawny and E. Jaroszkiewicz
Affiliation:
Keywords: EPR, radiation sterilization, radiodegradation, radiolytic yield, gamma radiation, electrons, ionizing radiation, chloramphenicol, radiostability, microbiological purity
Abstract: Ionizing radiation used for sterilization of drugs may lead to drug degradation and therefore essential element of the validation process is the choice of optimal conditions for sterilization, i.e. radiation dose and radiation source. This investigation examines and compares radiostability of derivatives of 1-phenylpropan-1-ol exposed to the same effective doses of ionizing radiation but emitted from different sources: gamma radiation (60Co) and high energy electrons emitted by linear electron accelerator. The drugs used in this investigation were chloramphenicol, its ester (chloramphenicol sodium succinate) and analog (thiamphenicol).
It was found that gamma radiation had a more destructive effect on drugs than high energy electrons. This was apparent from the change in the color intensity, increase in the concentration of free radicals, the number of radiolysis products and larger decrease in the drug content. The difference in the power between the two sources of ionizing radiation (1 kGy/h for 60Co and 10 kGy/s for high energy electrons) could account for that.
Export Options
About this article
Cite this article as:
Marciniec B., Stawny M. and Jaroszkiewicz E., Comparison of Influence of Gamma Rays and E-beam on Some Chloramphenicol Derivatives, Current Analytical Chemistry 2012; 8 (3) . https://dx.doi.org/10.2174/157341112801264941
DOI https://dx.doi.org/10.2174/157341112801264941 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
Call for Papers in Thematic Issues
Advancements in biomedicine, corrosion inhibition/monitoring, and lubrication of carbon dots
Carbon dots, a class of carbon-based nanomaterials, have garnered substantial interest in various scientific and engineering fields due to their unique properties, including excellent optical properties, outstanding biocompatibility, easy preparation, good dispersity, ultrasmall size, low toxicity and environmental friendliness. This special issue of Current Analytical Chemistry aims to showcase cutting-edge ...read more
Applications of artificial intelligence in chemical analysis
Artificial intelligence (AI) has demonstrated its versatility in almost all scientific fields, especially analytical chemistry, which is leading the way in the integration of AI. According to Chemical Abstract Services, one of the major disciplines contributing to AI-related publications and patents is analytical chemistry. That?s because techniques such as deep ...read more
Bioanalytical and Biosensor Technologies for Target Molecules
Bioanalytical and biosensor technologies constitute the core of detecting and sensing diverse molecules within living organisms, encompassing proteins, DNA, small molecular metabolites, and beyond. These molecules assume pivotal roles in biological processes, rendering their analysis and sensing indispensable for comprehending biological phenomena and unraveling disease mechanisms. In the current landscape ...read more
Biogeochemistry: global environmental research and management
his issue focuses on the bio-pathways of trace elements (Ni, Co, Cr, Mn, Cd, Pb, Zn and REE) in soil, plant and atmospheric systems. Specific interest in the application of phytotechnologies that utilise hyperaccumulator plants (agro/phytomining). On the basis of understanding the migration and transformation of trace elements in ecosystem, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
An Apple Plus a Brazil Nut a Day Keeps the Doctors Away: Antioxidant Capacity of Foods and their Health Benefits
Current Pharmaceutical Design Microfluidic Paper-based Device for Medicinal Diagnosis
Current Topics in Medicinal Chemistry Promising Potential of Dietary (Poly)Phenolic Compounds in the Prevention and Treatment of Diabetes Mellitus
Current Medicinal Chemistry Hematocrit-lowering Effect Following Inactivation of Renin-Angiotensin System with Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers
Current Topics in Medicinal Chemistry Water Soluble Vitamins and their Role in Diabetes and its Complications
Current Diabetes Reviews Consumption of Polyphenol Plants May Slow Aging and Associated Diseases
Current Pharmaceutical Design Legalon® SIL: The Antidote of Choice in Patients with Acute Hepatotoxicity from Amatoxin Poisoning
Current Pharmaceutical Biotechnology The Beneficial Effect of Physical Exercise on Inflammatory Makers in Older Individuals
Endocrine, Metabolic & Immune Disorders - Drug Targets Blood Derivates in Ocular Surface Regeneration
Recent Patents on Regenerative Medicine Shutting Down the Furnace: Preferential Killing of Cancer Cells with Mitochondrial-Targeting Molecules
Current Medicinal Chemistry Cachexia and Herbal Medicine: Perspective
Current Pharmaceutical Design Regulation of the Immune Response by Natural IgM: Lessons from Warm Autoimmune Hemolytic Anemia
Current Pharmaceutical Design Sodium-glucose Cotransporter 2 Inhibitors and the Risk of Diabetic Ketoacidosis; from Pathophysiology to Clinical Practice
Cardiovascular & Hematological Disorders-Drug Targets Bile Acids and Derivatives, Their Nuclear Receptors FXR, PXR and Ligands: Role in Health and Disease and Their Therapeutic Potential
Anti-Cancer Agents in Medicinal Chemistry Functional Nucleic Acids in High Throughput Screening and Drug Discovery
Combinatorial Chemistry & High Throughput Screening Effects of Polyphenol Administration to European Farmed Sea Bass (<i>Dicentrharcus labrax</i> L.): Special Focus on Hepatopancreas Morphology
Endocrine, Metabolic & Immune Disorders - Drug Targets Novel Superactive Leptin Antagonists and their Potential Therapeutic Applications
Current Pharmaceutical Design A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists
Mini-Reviews in Medicinal Chemistry Application of Bacterial Nanocellulose in Cancer Drug Delivery: A Review
Current Pharmaceutical Design microRNAs in the Regulation of Adipogenesis and Obesity
Current Molecular Medicine