Unusual Course of the Reaction of Lawesson’s Reagent with β-Phosphoryl- β’-carbethoxyhydrazones: First Synthesis of 5-Mercapto-3-(methylthiophosphoryl) pyrazoles

Title:Unusual Course of the Reaction of Lawesson’s Reagent with β-Phosphoryl- β’-carbethoxyhydrazones: First Synthesis of 5-Mercapto-3-(methylthiophosphoryl) pyrazoles

Volume: 9 Issue: 5

Author(s): Emna Chebil and Soufiane Touil

Affiliation:

Keywords: Hydrazones, Lawesson’s reagent, mercaptopyrazoles, pyrazoles, thiophosphorylpyrazoles, heterocyclic, agrochemistry, anticancer, antiviral, antimicrobial

Abstract: It is well known that Lawesson’s reagent (LR) reacts with hydrazone derivatives at 80 °C to yield 3-thioxo- 1,2,3-diazaphospholine derivatives. We show, in the present investigation, that the reaction of LR with β- phosphoryl-β’-carbethoxyhydrazones under the same conditions, took an entirely different course and gave a new type of pyrazole derivatives, the 5-mercapto-3-(methylthiophosphoryl)pyrazoles.

Cite this article as:

Chebil Emna and Touil Soufiane, Unusual Course of the Reaction of Lawesson’s Reagent with β-Phosphoryl- β’-carbethoxyhydrazones: First Synthesis of 5-Mercapto-3-(methylthiophosphoryl) pyrazoles, Letters in Organic Chemistry 2012; 9 (5) . https://dx.doi.org/10.2174/157017812801264764