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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Progress on Synthesis and Activities of Allosamidin and Its Analogues

Author(s): Gangliang Huang

Volume 12, Issue 7, 2012

Page: [665 - 670] Pages: 6

DOI: 10.2174/138955712800626700

Price: $65

Abstract

The pseudotrisaccharide allosamidin 1 is a potent family-18 chitinase inhibitor, and it demonstrates biological activities against insects and fungi. Recent development for the synthesis and activities of compound 1 and its analogues was reviewed. Huang et al. described the solid-phase synthesis of allosamidin 1 and its analogues, which were obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively. It indicated that di-N-acetyl-β-chitobiosyl allosamizoline was strongly against insect chitinase from Bombyx mori. Withers and his coworkers have synthesized chitobiose and chitotriose thiazolines, which exhibit chitinase inhibition activity.

Keywords: Allosamidin, analogues, synthesis, activities, recent development, β-linked, N-iodosuccinimide, oligosaccharides, trimethylsilyl trifluromethanesulfonate


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