Abstract
A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.
Keywords: Anticancer activity, Anti-inflammatory, 1, 4-benzodiazepines, Myeloperoxidase
Anti-Cancer Agents in Medicinal Chemistry
Title:Anticancer Activity and Anti-inflammatory Studies of 5-Aryl-1,4-benzodiazepine Derivatives
Volume: 12 Issue: 6
Author(s): Cortez-Maya Sandra, Cortes Cortes Eduardo, Hernandez-Ortega Simon, Ramirez Apan Teresa, Nieto Camacho Antonio, Irina V. Lijanova and Martinez-Garcia Marcos
Affiliation:
Keywords: Anticancer activity, Anti-inflammatory, 1, 4-benzodiazepines, Myeloperoxidase
Abstract: A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.
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Cite this article as:
Sandra Cortez-Maya, Cortes Eduardo Cortes, Simon Hernandez-Ortega, Apan Teresa Ramirez, Camacho Antonio Nieto, V. Lijanova Irina and Marcos Martinez-Garcia, Anticancer Activity and Anti-inflammatory Studies of 5-Aryl-1,4-benzodiazepine Derivatives, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (6) . https://dx.doi.org/10.2174/187152012800617713
DOI https://dx.doi.org/10.2174/187152012800617713 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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