Abstract
The industrial synthesis of pharmaceutical compounds often involves the use of organic solvents. Unfortunately, these reaction media are responsible for organic contaminations in the final product. In recent years, ionic liquids (ILs) have become the “green alternatives” of volatile organic solvents. Thus, the application of ILs instead of conventional reagents offer a new opportunity to solve problems of environmentally harmful solvents. This mini-review discusses a new application of ILs in laboratory-scale pharmaceutical synthesis.
Keywords: Active pharmaceutical ingredient, biocatalytic reaction, green chemistry, ionic liquid, RTILs, antiparasitic drugs, DMAP, NSAIDs, CPPO, BNCT, Prvadoline
Mini-Reviews in Organic Chemistry
Title:Ionic Liquids: A New Strategy in Pharmaceutical Synthesis
Volume: 9 Issue: 2
Author(s): Tomasz Siodmiak, Michal Piotr Marszall and Anna Proszowska
Affiliation:
Keywords: Active pharmaceutical ingredient, biocatalytic reaction, green chemistry, ionic liquid, RTILs, antiparasitic drugs, DMAP, NSAIDs, CPPO, BNCT, Prvadoline
Abstract: The industrial synthesis of pharmaceutical compounds often involves the use of organic solvents. Unfortunately, these reaction media are responsible for organic contaminations in the final product. In recent years, ionic liquids (ILs) have become the “green alternatives” of volatile organic solvents. Thus, the application of ILs instead of conventional reagents offer a new opportunity to solve problems of environmentally harmful solvents. This mini-review discusses a new application of ILs in laboratory-scale pharmaceutical synthesis.
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Siodmiak Tomasz, Piotr Marszall Michal and Proszowska Anna, Ionic Liquids: A New Strategy in Pharmaceutical Synthesis, Mini-Reviews in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157019312800604698
DOI https://dx.doi.org/10.2174/157019312800604698 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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