Abstract
This review summarizes recent research on biomarkers of tissue remodeling in different body fluids of patients suffering with pulmonary diseases. In particular we focus on elastin breakdown products, matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in syndromes such as chronic obstructive pulmonary disease, pulmonary hypertension, acute lung injury/acute respiratory distress syndrome and cystic fibrosis. Data from both preclinical disease models as well as clinical evaluation of the aforementioned biomarkers will be examined.
Keywords: Biomarker, pulmonary disease, desmosine, matrix metalloproteinase-2, -9, -12, tissue inhibitor of matrix metalloproteinase-4
Current Respiratory Medicine Reviews
Title:Biomarkers of Lung Tissue Remodeling in Pulmonary Diseases: Implications for Clinical Practice and Research
Volume: 8 Issue: 2
Author(s): Frank Kramer, Alex Dusek
Affiliation:
Keywords: Biomarker, pulmonary disease, desmosine, matrix metalloproteinase-2, -9, -12, tissue inhibitor of matrix metalloproteinase-4
Abstract: This review summarizes recent research on biomarkers of tissue remodeling in different body fluids of patients suffering with pulmonary diseases. In particular we focus on elastin breakdown products, matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in syndromes such as chronic obstructive pulmonary disease, pulmonary hypertension, acute lung injury/acute respiratory distress syndrome and cystic fibrosis. Data from both preclinical disease models as well as clinical evaluation of the aforementioned biomarkers will be examined.
Export Options
About this article
Cite this article as:
Frank Kramer, Alex Dusek , Biomarkers of Lung Tissue Remodeling in Pulmonary Diseases: Implications for Clinical Practice and Research, Current Respiratory Medicine Reviews 2012; 8 (2) . https://dx.doi.org/10.2174/157339812799859770
DOI https://dx.doi.org/10.2174/157339812799859770 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Current and Emerging Therapies in Primary Myelofibrosis
Cardiovascular & Hematological Disorders-Drug Targets β3-Adrenoceptor Control of Lower Genitourinary Tract Organs and Function in Male: An Overview
Current Drug Targets GRK2 and Beta-Arrestins in Cardiovascular Disease: Established and Emerging Possibilities for Therapeutic Targeting
Current Molecular Pharmacology Subject Index to Volume 2
Current Medicinal Chemistry - Cardiovascular & Hematological Agents The Plasma and Tissue Kininogen-kallikrein-kinin System: Role in the Cardiovascular System
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Recent Progress in Pharmacological Research of Antioxidants in Pathological Conditions: Cardiovascular Health
Recent Patents on Anti-Infective Drug Discovery Cardiovascular Imaging in Thromboembolic Risk Stratification for Atrial Fibrillation: Recent Patents and Current Practice
Recent Patents on Medical Imaging A New Biomarker with High Outcome Prediction in IgA Nephropathy
Recent Patents on Biomarkers Multi-Constituent Cardiovascular Pills (MCCP) - Challenges and Promises of Population-Based Prophylactic Drug Therapy for Prevention of Heart Attack
Current Pharmaceutical Design Properties and Therapeutic Potential of Transient Receptor Potential Channels with Putative Roles in Adversity: Focus on TRPC5, TRPM2 and TRPA1
Current Drug Targets Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors
Current Medicinal Chemistry Therapeutic Implications of Immune-endocrine Interactions in the Critically Ill Patients
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Monoamine Receptors in the Regulation of Feeding Behaviour and Energy Balance
CNS & Neurological Disorders - Drug Targets Urine IL-18 is a Biomarker of Early Acute Kidney Injury (AKI)
Recent Patents on Biomarkers Traditional Risk Factors are Causally Related to Carotid Intima-Media Thickness Progression: Inferences from Observational Cohort Studies and Interventional Trials
Current Pharmaceutical Design X-Ray Versus Magnetic Resonance Imaging in Diabetic Foot Osteomyelitis: A Clinical Comparison
Current Diabetes Reviews Integrative Control of Gastrointestinal Motility by Nitric Oxide
Current Medicinal Chemistry The Polymorphism at the microRNA-155 Binding Site in the AGTR1 Gene is not Significantly Associated with Rheumatic Heart Disease in Saudi Arabia Population
MicroRNA Cancer Neovascularization and Proinflammatory Microenvironments
Current Cancer Drug Targets Perivascular Inflammation and Hypertensive Cardiovascular Remodeling
Current Hypertension Reviews