Abstract
Leishmaniasis is caused by protozoan parasites belonging to the genus Leishmania. According to WHO, leishmaniasis occurs in four continents and is considered to be endemic in 88 countries, 72 of which are developing countries. Intensive effort to investigate novel compounds to counter the parasites that are resistant to existing drug molecules is necessary. This review intends to give an outline of the present state of knowledge on antileishmanial drugs along with molecules that are currently under development as promising drug candidate. A brief discussion on some aspects of associated drug resistance is also considered.
Keywords: Leishmaniasis, parasitic protozoa, amastigote, diffuse cutaneous leishmaniasis (DCL), disseminated, phlebotomine sandfly, Chemotherapy, visceral and cutaneous sites of infection, immunocompromised patient, AIDS
Letters in Drug Design & Discovery
Title:Small Molecules Antileishmanials: A Review
Volume: 9 Issue: 5
Author(s): Akanksha Kulshrestha, Meenakshi Dhanawat, Nirupam Das, Sushant K. Shrivastava
Affiliation:
Keywords: Leishmaniasis, parasitic protozoa, amastigote, diffuse cutaneous leishmaniasis (DCL), disseminated, phlebotomine sandfly, Chemotherapy, visceral and cutaneous sites of infection, immunocompromised patient, AIDS
Abstract: Leishmaniasis is caused by protozoan parasites belonging to the genus Leishmania. According to WHO, leishmaniasis occurs in four continents and is considered to be endemic in 88 countries, 72 of which are developing countries. Intensive effort to investigate novel compounds to counter the parasites that are resistant to existing drug molecules is necessary. This review intends to give an outline of the present state of knowledge on antileishmanial drugs along with molecules that are currently under development as promising drug candidate. A brief discussion on some aspects of associated drug resistance is also considered.
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Akanksha Kulshrestha, Meenakshi Dhanawat, Nirupam Das, Sushant K. Shrivastava , Small Molecules Antileishmanials: A Review, Letters in Drug Design & Discovery 2012; 9 (5) . https://dx.doi.org/10.2174/157018012800389359
DOI https://dx.doi.org/10.2174/157018012800389359 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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