An Efficient Synthesis, Characterization and Antimicrobial Screening of N-substituted 2-(piperidin-4-yl)-2H-benzo[d] [1, 2, 3] Triazoles

Title:An Efficient Synthesis, Characterization and Antimicrobial Screening of N-substituted 2-(piperidin-4-yl)-2H-benzo[d] [1, 2, 3] Triazoles

Volume: 9 Issue: 5

Author(s): Jalapathi Pochampalli, Devender Mandala, Nalla Umapathireddy, Pompu Rajakomuraiah

Affiliation:

Keywords: broad spectrum activity, antiseptic, anticoagulant agent, bio active heterocyclic molecules, stock solution, anti-acetyl cholinesterase, antibacterial activities, Staph. Aurius, K2CO3-acetonitrile, Klebsiella pneumonia

Abstract: A new series N-substituted -2-piperidine-4-yl-2H-benzotriazole (6a-6r) have been synthesized from 4-oxopiperidine- 1-carbaxylic acid tert-butyl ester. The new compounds were screened for their antibacterial activity against Gram positive bacteria (Bacillus subtilis, Bacillus megaterium, Bacillus pumilis, Staphylococcus aurius, Enterobactor aerogens and Streptococcus pyrogens) and Gram negative bacteria (Escherichia coli, Proteus vulgaris, Proteus mirabilis and Klebsiella pneumonia). Compounds 6a, 6b, 6g, 6h, 6k, 6q and 6r showed significant anti bacterial activity. The compounds have also been screened for antifungal activity viz Candida albicance, Fusarium oxysporum, Drechslera halodes,and Colletotrichum falcatum. Compounds 6a, 6b, 6d, 6g, 6h and 6r showed significant antifungal activity.

Cite this article as:

Jalapathi Pochampalli, Devender Mandala, Nalla Umapathireddy, Pompu Rajakomuraiah , An Efficient Synthesis, Characterization and Antimicrobial Screening of N-substituted 2-(piperidin-4-yl)-2H-benzo[d] [1, 2, 3] Triazoles, Letters in Drug Design & Discovery 2012; 9 (5) . https://dx.doi.org/10.2174/157018012800389304