In Vitro Antioxidant Activity of Some Novel Synthetic Mononuclear Ruthenium (II) Compounds

Title:In Vitro Antioxidant Activity of Some Novel Synthetic Mononuclear Ruthenium (II) Compounds

Volume: 9 Issue: 4

Author(s): Shyam Sunder Anchuri, Sreekanth Thota, Rajeshwar Yerra, Satyavati Dhulipala

Affiliation:

Keywords: Antioxidant, ABTS, DMPD, DPPH, FRAP, NBT, Ruthenium compounds

Abstract: The present work was aimed that in vitro antioxidant activity of some novel synthetic mononuclear Ruthenium (II) compounds namely, Ru (1, 10-phenanthroline)2(2-nitro Phenyl thiosemicarbazone)Cl2 (compound R1) and Ru (1, 10- phenanthroline)2(2-hydroxy-phenyl thiosemicarbazone)Cl2 (compound R2) using [2, 29-azinobis-(3-ethylbenzothiazoline- 6-sulfonic acid)] (ABTS), Ferric reducing antioxidant power (FRAP), N, N-dimethyl-p-phenylenediamine (DMPD), 1, 1- diphenyl-2-picryl hydrazine (DPPH) and Nitro blue tetrazolium (NBT) assays. The results concluded that both the compounds (R1&R2) exhibited a significant antioxidant activity. But compared to reference standards, R1 was found to be better free radical scavenging activity than R2.

Cite this article as:

Shyam Sunder Anchuri, Sreekanth Thota, Rajeshwar Yerra, Satyavati Dhulipala , In Vitro Antioxidant Activity of Some Novel Synthetic Mononuclear Ruthenium (II) Compounds, Letters in Drug Design & Discovery 2012; 9 (4) . https://dx.doi.org/10.2174/157018012799859927