Abstract
Various supramolecular systems can be used as drug carriers to alter physicochemical and pharmacokinetic characteristics of drugs. Representative supramolecular systems that can be used for this purpose include surfactant/polymer micelles, (micro)emulsions, liposomes, layer-by-layer assemblies, and various molecular conjugates. Notably, liposomes are established supramolecular drug carriers, which have already been marketed in formulations including AmBisome® (for treatment of fungal infection), Doxil® (for Kaposi’s sarcoma), and Visudyne® (for age-related macular degeneration and choroidal neovascularization). Microemulsions have been used oral drug delivery of poorly soluble drugs due to improvements in bioavailability and predictable of absorption behavior. Neoral®, an immunosuppressant used after transplant operations, is one of the most famous microemulsion-based drugs. Polymer micelles are being increasingly investigated as novel drug carriers and some formulations have already been tested in clinical trials. Supramolecular systems can be functionalized by designing the constituent molecules to achieve efficient delivery of drugs to desired sites in the body. In this review, representative supramolecular drug delivery systems, that may improve usability of candidate drugs or add value to existing drugs, are introduced.
Keywords: Drug delivery, emulsion, microemulsion, hybrid, micelle, polymer micelle, layer-by-layer, liposome, molecular conjugate, cyclodextrin, self-assembly, supramolecular chemistry
Current Medicinal Chemistry
Title:Supramolecular Approaches for Drug Development
Volume: 19 Issue: 15
Author(s): K. Kawakami, M. Ebara, H. Izawa, N. M. Sanchez-Ballester, J. P. Hill, K. Ariga
Affiliation:
Keywords: Drug delivery, emulsion, microemulsion, hybrid, micelle, polymer micelle, layer-by-layer, liposome, molecular conjugate, cyclodextrin, self-assembly, supramolecular chemistry
Abstract: Various supramolecular systems can be used as drug carriers to alter physicochemical and pharmacokinetic characteristics of drugs. Representative supramolecular systems that can be used for this purpose include surfactant/polymer micelles, (micro)emulsions, liposomes, layer-by-layer assemblies, and various molecular conjugates. Notably, liposomes are established supramolecular drug carriers, which have already been marketed in formulations including AmBisome® (for treatment of fungal infection), Doxil® (for Kaposi’s sarcoma), and Visudyne® (for age-related macular degeneration and choroidal neovascularization). Microemulsions have been used oral drug delivery of poorly soluble drugs due to improvements in bioavailability and predictable of absorption behavior. Neoral®, an immunosuppressant used after transplant operations, is one of the most famous microemulsion-based drugs. Polymer micelles are being increasingly investigated as novel drug carriers and some formulations have already been tested in clinical trials. Supramolecular systems can be functionalized by designing the constituent molecules to achieve efficient delivery of drugs to desired sites in the body. In this review, representative supramolecular drug delivery systems, that may improve usability of candidate drugs or add value to existing drugs, are introduced.
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Cite this article as:
K. Kawakami, M. Ebara, H. Izawa, N. M. Sanchez-Ballester, J. P. Hill, K. Ariga , Supramolecular Approaches for Drug Development, Current Medicinal Chemistry 2012; 19 (15) . https://dx.doi.org/10.2174/092986712800269254
DOI https://dx.doi.org/10.2174/092986712800269254 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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