Abstract
On December 23rd, 1971, President Richard Nixon signed the National Cancer Act and invested more than $ 100 million “to launch an intensive campaign to find a cure for cancer”. Today, despite these considerable efforts, cancer still remains a very aggressive silent killer all over the world.
Moreover, over the last decade, novel synthetic chemotherapeutic agents currently in use in the clinics did not succeed in fulfilling their expectations even though they are very cost-intensive. In parallel, there is increasing evidence for the potential of plant-derived compounds on the inhibition of different steps of tumor genesis and associated inflammatory processes, underlining the importance of these products in cancer prevention and therapy.
This review summarizes the impact of selected natural compounds on the eight major alterations, known as the cancer hallmarks, and also on their two enabling characteristics that were coined by Hanahan and Weinberg earlier. Altogether these ten alterations are responsible for the progressive transition of healthy cells into neoplastic ones and their further dissemination in the body.
With this review, we try to highlight molecular mechanisms by which plant extracts and their purified active components fight and overcome these pathological variations of the cell signaling pathways for the improvement of prevention and therapy. We truly believe that all diseases can be found in Nature and that Nature also provides the efficient cures.
Keywords: Plant compounds, cancer hallmarks, inflammation signaling, cell cycle, cell death, immune system, tumor microenvironment
Current Medicinal Chemistry
Title:Power from the Garden: Plant Compounds as Inhibitors of the Hallmarks of Cancer
Volume: 19 Issue: 14
Author(s): B. Orlikova, M. Diederich
Affiliation:
Keywords: Plant compounds, cancer hallmarks, inflammation signaling, cell cycle, cell death, immune system, tumor microenvironment
Abstract: On December 23rd, 1971, President Richard Nixon signed the National Cancer Act and invested more than $ 100 million “to launch an intensive campaign to find a cure for cancer”. Today, despite these considerable efforts, cancer still remains a very aggressive silent killer all over the world.
Moreover, over the last decade, novel synthetic chemotherapeutic agents currently in use in the clinics did not succeed in fulfilling their expectations even though they are very cost-intensive. In parallel, there is increasing evidence for the potential of plant-derived compounds on the inhibition of different steps of tumor genesis and associated inflammatory processes, underlining the importance of these products in cancer prevention and therapy.
This review summarizes the impact of selected natural compounds on the eight major alterations, known as the cancer hallmarks, and also on their two enabling characteristics that were coined by Hanahan and Weinberg earlier. Altogether these ten alterations are responsible for the progressive transition of healthy cells into neoplastic ones and their further dissemination in the body.
With this review, we try to highlight molecular mechanisms by which plant extracts and their purified active components fight and overcome these pathological variations of the cell signaling pathways for the improvement of prevention and therapy. We truly believe that all diseases can be found in Nature and that Nature also provides the efficient cures.
Export Options
About this article
Cite this article as:
B. Orlikova, M. Diederich , Power from the Garden: Plant Compounds as Inhibitors of the Hallmarks of Cancer, Current Medicinal Chemistry 2012; 19 (14) . https://dx.doi.org/10.2174/092986712800228998
DOI https://dx.doi.org/10.2174/092986712800228998 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Application of Bacterial Nanocellulose in Cancer Drug Delivery: A Review
Current Pharmaceutical Design Involvement of CD24 in Multiple Cancer Related Pathways Makes It an Interesting New Target for Cancer Therapy
Current Cancer Drug Targets Potential Gene Therapy Strategies for Cancer Stem Cells
Current Gene Therapy UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase- 6 (pp-GalNAc-T6): Role in Cancer and Prospects as a Drug Target
Current Cancer Drug Targets Small Molecule Toxins Targeting Tumor Receptors
Current Pharmaceutical Design Botulinum Toxin a in Prostate Disease: A Venom from Bench to Bed-Side
Current Drug Delivery Vitamin D and Infectious Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Comparison of the Structure and Biological Activities of Wild-type and Mutant Liver-targeting Peptide Modified Recombinant Human Endostatin (rES-CSP) in Human Hepatocellular Carcinoma HepG2 Cells
Protein & Peptide Letters Anti-Angiogenesis in the Treatment of Genito-Urinary Cancers: Last Updates
Current Angiogenesis (Discontinued) Regulation of P2X3 Receptor Structure and Function
CNS & Neurological Disorders - Drug Targets Stem Cell Function, Self-Renewal, Heterogeneity, and Regenerative Potential in Skeletal Muscle Stem Cells
Recent Patents on Regenerative Medicine Improvements in Algorithms for Phenotype Inference: The NAT2 Example
Current Drug Metabolism Remodelling of the Ca2+ Toolkit in Tumor Endothelium as a Crucial Responsible for the Resistance to Anticancer Therapies
Current Signal Transduction Therapy Advances in Chemotherapy and Targeted Systemic Therapies for Urothelial Cancer
Current Drug Therapy β -Glucans and their Applications in Cancer Therapy: Focus on human studies
Anti-Cancer Agents in Medicinal Chemistry A Review on Synthetic and Natural Steroid Dimers: 1997-2006
Current Medicinal Chemistry Heat Shock Proteins (HSPs) Based Anti-Cancer Vaccines
Current Molecular Medicine Secondary Metabolites from Cordyceps Species and Their Antitumor Activity Studies
Recent Patents on Biotechnology Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents
Current Medicinal Chemistry Stem Cell Therapy: A Promising Approach in Treatment of COVID-19
Current Stem Cell Research & Therapy