Abstract
O-Acyl isodipeptides are prepared by coupling Boc-Ser/Thr-OBzl with Fmoc-Xaa-OH employing COMU, well known third generation peptide coupling agent. The reaction proceeds with high yield and the chemical homogeneity of the synthesized molecules were established via chiral HPLC analyses. The O-acyl isodipeptide units play crucial role in the success of ‘click peptide’ protocol employed for assembling ‘difficult sequence’ peptides.
Keywords: O-acyl isodipeptide, click peptide, difficult sequence, COMU, esterification
Protein & Peptide Letters
Title:Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU
Volume: 19 Issue: 4
Author(s): M. Samarasimhareddy, Hosahalli P. Hemantha, Kuppanna Ananda and Vommina V. Sureshbabu
Affiliation:
Keywords: O-acyl isodipeptide, click peptide, difficult sequence, COMU, esterification
Abstract: O-Acyl isodipeptides are prepared by coupling Boc-Ser/Thr-OBzl with Fmoc-Xaa-OH employing COMU, well known third generation peptide coupling agent. The reaction proceeds with high yield and the chemical homogeneity of the synthesized molecules were established via chiral HPLC analyses. The O-acyl isodipeptide units play crucial role in the success of ‘click peptide’ protocol employed for assembling ‘difficult sequence’ peptides.
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Cite this article as:
Samarasimhareddy M., P. Hemantha Hosahalli, Ananda Kuppanna and V. Sureshbabu Vommina, Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU, Protein & Peptide Letters 2012; 19 (4) . https://dx.doi.org/10.2174/092986612799789413
DOI https://dx.doi.org/10.2174/092986612799789413 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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