Abstract
Background: Organ dysfunctions and medical complications, such as renal failure, liver impairment, coagulation disorders, cardiovascular and respiratory illnesses, may hamper an adequate pain management in haematological patients.
Aim: To summarize current knowledge on pain management in hematological patients presenting major organ dysfunctions and comorbidity. We also attempted to provide recommendations to optimize analgesia and to minimize side effects in the setting of medically compromised and frail haematological patients.
Methods: A systematic search of the literature, using relevant key words, was conducted in PubMed.
Results and conclusions: Pain in hematological patients is a common symptom and is often multi-factorial. Most pharmacotherapeutic measures, including causal therapies, analgesics and adjuvant agents routinely applied in pain management, may also be used in the setting of clinical frailty and medical comorbidities; however, comprehensive clinical and functional patient’s evaluations and a careful consideration of expected benefits and potential adverse events are required.
Keywords: Analgesics, anticoagulant oral therapy, blood diseases, cardiovascular diseases, chronic illnesses, coagulation defects, haematology, heparin, liver dysfunctions, liver cirrhosis, liver failure, medical complications, non steroidal antiinflammatory drugs (NSAIDs), opioids, oral anticoagulant therapy, pain, pain management, paracetamol, renal impairment, thrombocytopenia
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title:Pain Management in Hematological Patients with Major Organ Dysfunctions and Comorbid Illnesses
Volume: 10 Issue: 2
Author(s): Pasquale Niscola, Andrea Tendas, Marco Giovannini, Laura Scaramucci, Luca Cupelli, Michele Ferrannini, Gregorio Antonio Brunetti, Francesco Bondanini, Roberto Palumbo, Alessio Perrotti, Claudio Romani, Claudio Cartoni, Fabio Efficace and Paolo de Fabritiis
Affiliation:
Keywords: Analgesics, anticoagulant oral therapy, blood diseases, cardiovascular diseases, chronic illnesses, coagulation defects, haematology, heparin, liver dysfunctions, liver cirrhosis, liver failure, medical complications, non steroidal antiinflammatory drugs (NSAIDs), opioids, oral anticoagulant therapy, pain, pain management, paracetamol, renal impairment, thrombocytopenia
Abstract: Background: Organ dysfunctions and medical complications, such as renal failure, liver impairment, coagulation disorders, cardiovascular and respiratory illnesses, may hamper an adequate pain management in haematological patients.
Aim: To summarize current knowledge on pain management in hematological patients presenting major organ dysfunctions and comorbidity. We also attempted to provide recommendations to optimize analgesia and to minimize side effects in the setting of medically compromised and frail haematological patients.
Methods: A systematic search of the literature, using relevant key words, was conducted in PubMed.
Results and conclusions: Pain in hematological patients is a common symptom and is often multi-factorial. Most pharmacotherapeutic measures, including causal therapies, analgesics and adjuvant agents routinely applied in pain management, may also be used in the setting of clinical frailty and medical comorbidities; however, comprehensive clinical and functional patient’s evaluations and a careful consideration of expected benefits and potential adverse events are required.
Export Options
About this article
Cite this article as:
Niscola Pasquale, Tendas Andrea, Giovannini Marco, Scaramucci Laura, Cupelli Luca, Ferrannini Michele, Antonio Brunetti Gregorio, Bondanini Francesco, Palumbo Roberto, Perrotti Alessio, Romani Claudio, Cartoni Claudio, Efficace Fabio and de Fabritiis Paolo, Pain Management in Hematological Patients with Major Organ Dysfunctions and Comorbid Illnesses, Cardiovascular & Hematological Agents in Medicinal Chemistry 2012; 10 (2) . https://dx.doi.org/10.2174/187152512800388902
DOI https://dx.doi.org/10.2174/187152512800388902 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
Call for Papers in Thematic Issues
Medicinal Plants with Beneficial Properties on Diabetes and Hypertension
Diabetes and hypertension are real scourges of the 21st century. It is imperative to act in order to find innovative solutions to this problem. Taking medications such as hypoglycemic and antihypertensive drugs may aggravate certain underlying comorbidities, such as chronic kidney disease and cardiovascular disease. This significant drawback therefore requires ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Green Tea Attenuates Cardiovascular Remodeling and Metabolic Symptoms in High Carbohydrate-Fed Rats
Current Pharmaceutical Biotechnology Hemolysis-Associated Pulmonary Hypertension in Sickle Cell Disease: Global Disruption of the Arginine-Nitric Oxide Pathway
Current Hypertension Reviews Differential Developmental Origin of Arteries: Impact on Angiogenesis and Arteriogenesis
Medicinal Chemistry Reviews - Online (Discontinued) Employment of Quality by Design Approach via Response Surface Methodology to Optimize and Develop Modified-release Formulation of Hydrochlorothiazide
Current Computer-Aided Drug Design Developing Stress Assessment forms for Thai Cancer Patients: The Thai Version of the Modified Symptoms of Stress Inventory (Modified SOSI)
Current Psychiatry Research and Reviews Value of Real Time Three Dimensional Transesophageal Echocardiography in General Cardiology Practice
Recent Patents on Medical Imaging Blood Atherogenicity as a Target for Anti-atherosclerotic Therapy
Current Pharmaceutical Design Targeting TNF-Alpha in HIV-1 Infection
Current Drug Targets Recent Progress of Medicinal Chemistry Research on Peroxisome Proliferator-Activated Receptor (PPAR) Ligands for the Treatment of Metabolic Syndrome
Current Bioactive Compounds MicroRNAs in Peripheral Artery Disease
Current Topics in Medicinal Chemistry Mitochondrially Targeted Antioxidants for the Treatment of Cardiovascular Diseases
Recent Patents on Cardiovascular Drug Discovery Anaemia in Diabetes: An Emerging Complication of Microvascular Disease
Current Diabetes Reviews Matrix Metalloproteinases as Valid Clinical Target
Current Pharmaceutical Design Heterogeneity of Pre-diabetes and Type 2 Diabetes: Implications for Prediction, Prevention and Treatment Responsiveness
Current Diabetes Reviews Pre-Emptive Conditioning of the Ischemic Heart
Cardiovascular & Hematological Agents in Medicinal Chemistry Aldose Reductase: A Multi-disease Target
Current Enzyme Inhibition Vascular Effects of Ambient Pollutant Particles and Metals
Current Vascular Pharmacology Postprandial Hypertriglyceridaemia Revisited in the Era of Non-Fasting Lipid Profile Testing: A 2019 Expert Panel Statement, Main Text
Current Vascular Pharmacology Biomarkers in Cardiomyopathies and Prediction of Sudden Cardiac Death
Current Pharmaceutical Biotechnology The Lung Disease of Rheumatoid Arthritis
Current Respiratory Medicine Reviews