Abstract
Macrocyclic lactones (MLs), exemplified by the prototype of the class, ivermectin (IVM), are mainstays of programs for the control of nematode and arthropod parasites and pests. Since their introduction 30 years ago, research has revealed that they act on a family of ligand-gated chloride channels gated by glutamate, which is largely restricted to animals in the phyla Nematoda and Arthropoda. Studies on IVM in model organisms have contributed greatly to our understanding of ML pharmacology, but our understanding of the basis for differences among species and among MLs in potency and spectrum remains far from complete.
Keywords: Nematode, parasite, arthropod, glutamate-gated chloride channel, ivermectin
Current Pharmaceutical Biotechnology
Title:Macrocyclic Lactone Anthelmintics: Spectrum of Activity and Mechanism of Action
Volume: 13 Issue: 6
Author(s): Timothy G. Geary and Yovany Moreno
Affiliation:
Keywords: Nematode, parasite, arthropod, glutamate-gated chloride channel, ivermectin
Abstract: Macrocyclic lactones (MLs), exemplified by the prototype of the class, ivermectin (IVM), are mainstays of programs for the control of nematode and arthropod parasites and pests. Since their introduction 30 years ago, research has revealed that they act on a family of ligand-gated chloride channels gated by glutamate, which is largely restricted to animals in the phyla Nematoda and Arthropoda. Studies on IVM in model organisms have contributed greatly to our understanding of ML pharmacology, but our understanding of the basis for differences among species and among MLs in potency and spectrum remains far from complete.
Export Options
About this article
Cite this article as:
G. Geary Timothy and Moreno Yovany, Macrocyclic Lactone Anthelmintics: Spectrum of Activity and Mechanism of Action, Current Pharmaceutical Biotechnology 2012; 13 (6) . https://dx.doi.org/10.2174/138920112800399077
DOI https://dx.doi.org/10.2174/138920112800399077 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pin1: A New Genetic Link between Alzheimer’s Disease, Cancer and Aging
Current Aging Science Pathophysiology of Blood-Spinal Cord Barrier in Traumatic Injury and Repair
Current Pharmaceutical Design Pituitary Adenylate Cyclase Activating Polypeptide: A Potential Neuroprotective Peptide
Current Pharmaceutical Design Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract
Current Pharmaceutical Design HIV-1, HCV and Alcohol in the CNS: Potential Interactions and Effects on Neuroinflammation
Current HIV Research Bladder Cancer Stem Cells
Current Stem Cell Research & Therapy Von Hippel-Lindau Disease
Current Molecular Medicine Cognitive Dysfunction in FMR1 Premutation Carriers
Current Psychiatry Reviews The 5-HT1B Receptor: A Novel Target for the Pathophysiology of Depression
Current Drug Targets Different Treatment Strategies for Pediatric Brain Tumors
Current Pediatric Reviews Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease
Current Neuropharmacology Polyglutamine Protein Trafficking and Neurodegeneration
Current Genomics Phytochemicals in the Treatment of Alzheimer’s Disease: A Systematic Review
Current Drug Targets Connecting the Brain and New Drug Targets for Schizophrenia
Current Pharmaceutical Design Alzheimers Disease: Interactions Between Cholinergic Functions and β- amyloid
Current Alzheimer Research Impaired Neurovascular Coupling in the APPxPS1 Mouse Model of Alzheimer’s Disease
Current Alzheimer Research Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?
Current Medicinal Chemistry Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs
Current Neuropharmacology Nongenomic Actions of Thyroid Hormones: From Basic Research to Clinical Applications. An Update
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Neuroprotective Effects of Lithium - Pointing out Protein Phosphatases as Drug Targets?
Current Medicinal Chemistry - Central Nervous System Agents