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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

One-Pot Synthesis of Bis(indolyl)methanes: Ruthenium-Catalyzed Reaction of Benzylic Alcoholes and Indoles

Author(s): Shiyong Zhang, Weiyong Fan, Hongen Qu, Chen Xiao, Ning Wang, Lei Shu, Qiaosheng Hu and Liangxian Liu

Volume 16, Issue 7, 2012

Page: [942 - 948] Pages: 7

DOI: 10.2174/138527212800194827

Price: $65

Abstract

RuCl3·3H2O was found to be an effective catalyst for one-pot reactions of benzylic alcoholes with indoles affording the corresponding bis(indolyl)methanes under air atmosphere at room temperature in moderate to excellent yields. It is noteworthy that the RuCl3·3H2O system displayed a preference for the primary versus secondary benzylic group of a benzylic diol in intramolecular competition experiments.

Keywords: Benzylic alcohol, Bis(indolyl)methane, RuCl3·3H2O, Indole.


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