Abstract
Pyridazin-3(2H)-ones are inexpensive, stable, and easily prepared heterocycles. Since pyridazin-3(2H)-ones readily form stable anions, and can act as good leaving group. Their utility as synthetic auxiliaries was recently demonstrated by Yoon’s group. 2- Substituted-pyridazin-3(2H)-ones are also useful both the electrophilic agents and equivalents for the functionalization of the electron rich compounds and active methylenes, and synthones. 2-Substituted-pyridazin-3(2H)-ones are novel green agents because that can be recovered quantitatively and recycled. In this review, the preparation and the synthetic application of 2-substituted-pyridazin-3(2H)-ones are described.
Keywords: Acylation, Cyanation, Electrophilic halogenation, N-nitration, Coupling agent, Lactonization, N-arylsulfonation, 2-substitutedpyridazin- 3(2H)-one.
Current Organic Chemistry
Title:2-Substituted-pyridazin-3(2H)-ones as Green Electrophilic Agents in Synthesis
Volume: 16 Issue: 7
Author(s): Gi Hyeon Sung, Bo Ram Kim, Sang-Gyeong Lee, Jeum-Jong Kim and Yong-Jin Yoon
Affiliation:
Keywords: Acylation, Cyanation, Electrophilic halogenation, N-nitration, Coupling agent, Lactonization, N-arylsulfonation, 2-substitutedpyridazin- 3(2H)-one.
Abstract: Pyridazin-3(2H)-ones are inexpensive, stable, and easily prepared heterocycles. Since pyridazin-3(2H)-ones readily form stable anions, and can act as good leaving group. Their utility as synthetic auxiliaries was recently demonstrated by Yoon’s group. 2- Substituted-pyridazin-3(2H)-ones are also useful both the electrophilic agents and equivalents for the functionalization of the electron rich compounds and active methylenes, and synthones. 2-Substituted-pyridazin-3(2H)-ones are novel green agents because that can be recovered quantitatively and recycled. In this review, the preparation and the synthetic application of 2-substituted-pyridazin-3(2H)-ones are described.
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Cite this article as:
Hyeon Sung Gi, Ram Kim Bo, Lee Sang-Gyeong, Kim Jeum-Jong and Yoon Yong-Jin, 2-Substituted-pyridazin-3(2H)-ones as Green Electrophilic Agents in Synthesis, Current Organic Chemistry 2012; 16 (7) . https://dx.doi.org/10.2174/138527212800194773
DOI https://dx.doi.org/10.2174/138527212800194773 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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