Abstract
Formal [3+3] cyclocondensation reactions of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with functionalized and nonfunctionalized 1-alkyl- and 1-aryl-3-alkoxy-2-en-1-ones, 1,1-dichloro-3-buten-2-ones, 3-acyl-4,5-dihydrofurans and other related 1,3- dielectrophiles provide a convenient and regioselective approach to various highly substituted, functionalized phenols which are not readily available by other methods.
Keywords: Cyclization, Cyclocondensation, Functionalized phenols, Regioselectivity
Current Organic Chemistry
Title:Diversity-Oriented Synthesis of Functionalized Phenols by Regioselective [3+3] Cyclocondensations of 1,3-Bis(silyloxy)-1,3-butadienes with 3-Alkoxy-2-en-1-ones and Related Substrates
Volume: 16 Issue: 5
Author(s): Gnuni Karapetyan, Tuan T. Dang, Muhammad Sher, Tariel V. Ghochikyan, Ashot Saghyan, Peter Langer
Affiliation:
Keywords: Cyclization, Cyclocondensation, Functionalized phenols, Regioselectivity
Abstract:
Formal [3+3] cyclocondensation reactions of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with functionalized and nonfunctionalized 1-alkyl- and 1-aryl-3-alkoxy-2-en-1-ones, 1,1-dichloro-3-buten-2-ones, 3-acyl-4,5-dihydrofurans and other related 1,3- dielectrophiles provide a convenient and regioselective approach to various highly substituted, functionalized phenols which are not readily available by other methods.
Export Options
About this article
Cite this article as:
Gnuni Karapetyan, Tuan T. Dang, Muhammad Sher, Tariel V. Ghochikyan, Ashot Saghyan, Peter Langer , Diversity-Oriented Synthesis of Functionalized Phenols by Regioselective [3+3] Cyclocondensations of 1,3-Bis(silyloxy)-1,3-butadienes with 3-Alkoxy-2-en-1-ones and Related Substrates, Current Organic Chemistry 2012; 16 (5) . https://dx.doi.org/10.2174/138527212799859372
DOI https://dx.doi.org/10.2174/138527212799859372 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Novel 4-Oxothienopyrimidinyl Propanoic Acid Derivatives as AMPActivated Protein Kinase (AMPK) Activators
Letters in Drug Design & Discovery Thiazolidin-4-one Derivatives as Central Nervous System Potential Agents
Central Nervous System Agents in Medicinal Chemistry Gene Expression Analysis for High Throughput Screening Applications
Combinatorial Chemistry & High Throughput Screening Subject Index To Volume 6
Anti-Cancer Agents in Medicinal Chemistry Advances in Antiplatelet Therapy for Stroke Prevention: the New P2Y12 antagonists
Current Drug Targets Antiviral Strategies Against Human Coronaviruses
Infectious Disorders - Drug Targets Synthesis of Some Novel 4-(Arylideneamino)-N'-((2-chloro-8-methylquinolin- 3-yl)methylene)-3-phenyl-2-thioxo-2,3-dihydrothiazole-5-carbohydrazides as Potential Antimicrobial Agents
Letters in Drug Design & Discovery The Development of MetAP-2 Inhibitors in Cancer Treatment
Current Medicinal Chemistry Benzimidazole Heterocycle as a Privileged Scaffold in Antiviral Agents
Mini-Reviews in Organic Chemistry Mycoplasma pneumoniae: Does it have a Role in Asthma Pathogenesis?
Current Pediatric Reviews Flavonoids as P-gp Inhibitors: A Systematic Review of SARs
Current Medicinal Chemistry Heterocyclic Moieties as HDAC Inhibitors: Role in Cancer Therapeutics
Mini-Reviews in Medicinal Chemistry Novel Classes of Dimer Antitumour Drug Candidates
Current Pharmaceutical Design Role of Mitochondrial Translocator Protein (18 kDa) on Mitochondrial- Related Cell Death Processes
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Targeting Protein-Protein and Protein-Nucleic Acid Interactions for Anti-HIV Therapy
Current Pharmaceutical Design Gene Therapy for Familial Hypercholesterolemia
Current Pharmaceutical Design It is Not Always COVID-19: Case Report about an Undiagnosed HIV Man with Dyspnea
Current HIV Research Site-Selective Labeling Strategies for Screening by NMR
Combinatorial Chemistry & High Throughput Screening Impact of Traditional Plants and their Secondary Metabolites in the Discovery of COVID-19 Treatment
Current Pharmaceutical Design Computational Methods for the Identification and Optimisation of High Quality Leads
Combinatorial Chemistry & High Throughput Screening