Abstract
The simple sphingolipids ceramide, sphingosine, ceramide 1-phosphate and sphingosine 1-phosphate, and their metabolizing enzymes are implicated in the regulation of vital cellular functions, including angiogenesis, cell differentiation, migration, and cell growth and death. These sphingolipids are also involved in the establishment and progression of many illnesses including cardiovascular diseases such as atherosclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's diseases, chronic inflammation, and cancer. Therefore, the development of inhibitors of the enzymes that are responsible for the synthesis and degradation of these metabolites may be essential tools for studying normal cell metabolism as well as for establishing new therapeutic strategies for treatment of disease.
Keywords: Apoptosis, cell proliferation, cell migration, inflammation, ceramides, ceramide-1-phosphate, sphingolipids, sphingosine 1-phosphate, atherosclerosis, ageing
Current Enzyme Inhibition
Title:Inhibition of Ceramide Metabolism Key Enzymes and its Implication in Cell Physiology and Pathology
Volume: 7 Issue: 4
Author(s): Antonio Gomez-Munoz, Alberto Ouro, Lide Arana, Io-Guane Rivera, Marta Ordonez, Patricia Gangoiti, Miguel Trueba
Affiliation:
Keywords: Apoptosis, cell proliferation, cell migration, inflammation, ceramides, ceramide-1-phosphate, sphingolipids, sphingosine 1-phosphate, atherosclerosis, ageing
Abstract:
The simple sphingolipids ceramide, sphingosine, ceramide 1-phosphate and sphingosine 1-phosphate, and their metabolizing enzymes are implicated in the regulation of vital cellular functions, including angiogenesis, cell differentiation, migration, and cell growth and death. These sphingolipids are also involved in the establishment and progression of many illnesses including cardiovascular diseases such as atherosclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's diseases, chronic inflammation, and cancer. Therefore, the development of inhibitors of the enzymes that are responsible for the synthesis and degradation of these metabolites may be essential tools for studying normal cell metabolism as well as for establishing new therapeutic strategies for treatment of disease.
Export Options
About this article
Cite this article as:
Antonio Gomez-Munoz, Alberto Ouro, Lide Arana, Io-Guane Rivera, Marta Ordonez, Patricia Gangoiti, Miguel Trueba , Inhibition of Ceramide Metabolism Key Enzymes and its Implication in Cell Physiology and Pathology, Current Enzyme Inhibition 2011; 7 (4) . https://dx.doi.org/10.2174/157340811799860551
DOI https://dx.doi.org/10.2174/157340811799860551 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Focused Microarray Analysis: Characterization of Phenomes by Gene Expression Profiling
Current Pharmacogenomics Synthesis, Characterization and Screening for Analgesic and Anti-inflammatory activities of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Chemical Genomics and Emerging DNA Technologies in the Identification of Drug Mechanisms and Drug Targets
Current Topics in Medicinal Chemistry Biochemical Markers of Impending Psychosis
Current Pharmaceutical Design A Brief Review of circRNA Biogenesis, Detection, and Function
Current Genomics The Roles of Mesenchymal Stem Cells in Tissue Repair and Disease Modification
Current Stem Cell Research & Therapy Cariprazine in Bipolar Depression and Mania: State of the Art
CNS & Neurological Disorders - Drug Targets The Molecular Mechanism of <i>Scutellaria baicalensis</i> Georgi Stems and Leaves Flavonoids in Promoting Neurogenesis and Improving Memory Impairment by the PI3K-AKT-CREB Signaling Pathway in Rats
Combinatorial Chemistry & High Throughput Screening Editorial [ Hot Topic:Addiction and Pain: Cannabinoid and Opioid Interactions (Guest Editor: Sonia Tucci) ]
Current Drug Targets Metabolic Syndrome the Gynecologist’s Approach
Current Women`s Health Reviews Genipin Inhibits the Induction of Inducible Nitric Oxide Synthase Through the Inhibition of NF-κB Activation in Rat Hepatocytes
Drug Metabolism Letters Emerging Therapies for Diabetic Neuropathy: A Clinical Overview
Current Diabetes Reviews GuidAge Study: A 5-Year Double Blind, Randomised Trial of EGb 761 for the Prevention of Alzheimers Disease in Elderly Subjects with Memory Complaints. I. Rationale, Design and Baseline Data
Current Alzheimer Research Spirulina in Health Care Management
Current Pharmaceutical Biotechnology Meet the Editorial Board
Current Medicinal Chemistry Zinc Chloride Catalyzed Collective Synthesis of Arylmethylene Bis(3- hydroxy-2-cyclohexene-1-ones) and 1,8-Dioxo-octahydroxanthene/acridine Derivatives
Letters in Organic Chemistry Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases
Current Alzheimer Research Understanding the Molecular Properties and Metabolism of Top Prescribed Drugs
Current Topics in Medicinal Chemistry Road From Nose to Brain for Treatment of Alzheimer: The Bumps and Humps
CNS & Neurological Disorders - Drug Targets Molecular Targets of Tannic Acid in Alzheimer's Disease
Current Alzheimer Research