Abstract
The simple sphingolipids ceramide, sphingosine, ceramide 1-phosphate and sphingosine 1-phosphate, and their metabolizing enzymes are implicated in the regulation of vital cellular functions, including angiogenesis, cell differentiation, migration, and cell growth and death. These sphingolipids are also involved in the establishment and progression of many illnesses including cardiovascular diseases such as atherosclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's diseases, chronic inflammation, and cancer. Therefore, the development of inhibitors of the enzymes that are responsible for the synthesis and degradation of these metabolites may be essential tools for studying normal cell metabolism as well as for establishing new therapeutic strategies for treatment of disease.
Keywords: Apoptosis, cell proliferation, cell migration, inflammation, ceramides, ceramide-1-phosphate, sphingolipids, sphingosine 1-phosphate, atherosclerosis, ageing
Current Enzyme Inhibition
Title:Inhibition of Ceramide Metabolism Key Enzymes and its Implication in Cell Physiology and Pathology
Volume: 7 Issue: 4
Author(s): Antonio Gomez-Munoz, Alberto Ouro, Lide Arana, Io-Guane Rivera, Marta Ordonez, Patricia Gangoiti, Miguel Trueba
Affiliation:
Keywords: Apoptosis, cell proliferation, cell migration, inflammation, ceramides, ceramide-1-phosphate, sphingolipids, sphingosine 1-phosphate, atherosclerosis, ageing
Abstract:
The simple sphingolipids ceramide, sphingosine, ceramide 1-phosphate and sphingosine 1-phosphate, and their metabolizing enzymes are implicated in the regulation of vital cellular functions, including angiogenesis, cell differentiation, migration, and cell growth and death. These sphingolipids are also involved in the establishment and progression of many illnesses including cardiovascular diseases such as atherosclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's diseases, chronic inflammation, and cancer. Therefore, the development of inhibitors of the enzymes that are responsible for the synthesis and degradation of these metabolites may be essential tools for studying normal cell metabolism as well as for establishing new therapeutic strategies for treatment of disease.
Export Options
About this article
Cite this article as:
Antonio Gomez-Munoz, Alberto Ouro, Lide Arana, Io-Guane Rivera, Marta Ordonez, Patricia Gangoiti, Miguel Trueba , Inhibition of Ceramide Metabolism Key Enzymes and its Implication in Cell Physiology and Pathology, Current Enzyme Inhibition 2011; 7 (4) . https://dx.doi.org/10.2174/157340811799860551
DOI https://dx.doi.org/10.2174/157340811799860551 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Purinergic Signalling: What is Missing and Needed Next? The Use of Transgenic Mice, Crystallographic Analysis and MicroRNA
CNS & Neurological Disorders - Drug Targets Gene Therapy in the Transplantation of Allogeneic Organs and Stem Cells
Current Gene Therapy Exploring Mode of Phosphoramidon and Aβ Peptide Binding to hECE-1 by Molecular Dynamics and Docking Studies
Protein & Peptide Letters Clinical Features of Scleroderma-Like Disorders: A Challenge for the Rheumatologist
Current Rheumatology Reviews Synthetic and Natural Immunomodulators Acting as Interferon Inducers
Current Pharmaceutical Design Effect of a New Class of Compounds of the Group of Substituted 5R1, 6H2-1,3,4-thiadiazine-2-amines on the Inflammatory and Cytokine Response in Experimental Myocardial Infarction
Current Vascular Pharmacology Functional Interactions of Tau and their Relevance for Alzheimers Disease
Current Alzheimer Research The Impact of Dementia Development Concurrent with Parkinson's Disease: A New Perspective
CNS & Neurological Disorders - Drug Targets Brain Metabolism of Ethanol and Alcoholism: An Update
Current Drug Metabolism Molecular Mechanisms, Emerging Etiological Insights and Models to Test Potential Therapeutic Interventions in Alzheimers Disease
Current Alzheimer Research Group-Analysis of Resting-State fMRI Based on Bayesian Network: A Comparison of Three Virtual-Typical-Subject Methods
Neuroscience and Biomedical Engineering (Discontinued) Sleep Problems in Euthymic Bipolar Disorders: A Review of Clinical Studies
Current Psychiatry Reviews Evaluation of Self Monitoring of Blood Glucose in Non-Insulin-Treated Diabetic Patients by Randomized Controlled Trials: Little Bang for the Buck
Reviews on Recent Clinical Trials Preparation and Characterization of Diltiazem HCL Loaded Bovine Serum Albumin Nanoparticles by Desolvation Technique
Pharmaceutical Nanotechnology Design, Synthesis and Evaluation of Dual-targeting Prodrug Co-modified by Organic Amine and L-ascorbic Acid for CNS Delivery
Letters in Drug Design & Discovery The Role of Oxytocin in Neuropsychiatric Disorders
Current Medicinal Chemistry The Use of Stem Cells in Regenerative Medicine for Parkinson’s and Huntington’s Diseases
Current Medicinal Chemistry Recent Advances in Cancer Therapy: An Overview
Current Pharmaceutical Design Sex Steroids in Autoimmune Diseases
Current Topics in Medicinal Chemistry Pathophysiology and Treatment of Diabetic Peripheral Neuropathy: The Case for Diabetic Neurovascular Function as an Essential Component
Current Diabetes Reviews