Abstract
Src family of protein tyrosine kinases (SFKs) plays key roles in the regulation of signal transductions in cellular processes. However, hyper-activated SFKs lead to uncontrolled cell proliferation and cancers. Src-targeted compounds were developed to block the cell proliferation signal transductions for cancer therapy. Src kinase domain inhibitors were designed, synthesized and evaluated as anticancer agents, while the patents applied at the same time. Great progress has been made in the Src kinase inhibitor area. Herein, some predominant patents about Src kinase inhibitors of the recent years are reviewed.
Keywords: Anticancer, AZD-0530, BMS-354825, carcinogenesis, inhibitor, kinase domain, SKI-606, Src kinase
Current Medicinal Chemistry
Title:Novel Patented Src Kinase Inhibitor
Volume: 19 Issue: 12
Author(s): Xiao-Ling Lu, Xiao-Yu Liu, Xin Cao and Bing-Hua Jiao
Affiliation:
Keywords: Anticancer, AZD-0530, BMS-354825, carcinogenesis, inhibitor, kinase domain, SKI-606, Src kinase
Abstract: Src family of protein tyrosine kinases (SFKs) plays key roles in the regulation of signal transductions in cellular processes. However, hyper-activated SFKs lead to uncontrolled cell proliferation and cancers. Src-targeted compounds were developed to block the cell proliferation signal transductions for cancer therapy. Src kinase domain inhibitors were designed, synthesized and evaluated as anticancer agents, while the patents applied at the same time. Great progress has been made in the Src kinase inhibitor area. Herein, some predominant patents about Src kinase inhibitors of the recent years are reviewed.
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Cite this article as:
Lu Xiao-Ling, Liu Xiao-Yu, Cao Xin and Jiao Bing-Hua, Novel Patented Src Kinase Inhibitor, Current Medicinal Chemistry 2012; 19 (12) . https://dx.doi.org/10.2174/092986712800099802
DOI https://dx.doi.org/10.2174/092986712800099802 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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