Abstract
After the completion of the human genome sequence, international efforts have been directed to the characterization of the genomes of human-associated resident microbes. The Human Microbiome Project was launched in 2007 with the aim of sequencing the resident microbiota from different sites of the human body. In this paper, we introduce the Human Microbiome Project, the role of the human microbiome in health and disease, and the implications of the microbiome variations in personalized medicine and in pharmacomicrobiomics, which we define as the effect of microbiome variations on drug disposition, action, and toxicity.
Keywords: Metagenomics, microbiome, microbiota, next-generation sequencing, pharmacogenomics, personalized medicine
Current Pharmacogenomics and Personalized Medicine
Title: The Human Microbiome Project, Personalized Medicine and the Birth of Pharmacomicrobiomics
Volume: 8 Issue: 3
Author(s): Mariam Reyad Rizkallah, Rama Saad and Ramy Karam Aziz
Affiliation:
Keywords: Metagenomics, microbiome, microbiota, next-generation sequencing, pharmacogenomics, personalized medicine
Abstract: After the completion of the human genome sequence, international efforts have been directed to the characterization of the genomes of human-associated resident microbes. The Human Microbiome Project was launched in 2007 with the aim of sequencing the resident microbiota from different sites of the human body. In this paper, we introduce the Human Microbiome Project, the role of the human microbiome in health and disease, and the implications of the microbiome variations in personalized medicine and in pharmacomicrobiomics, which we define as the effect of microbiome variations on drug disposition, action, and toxicity.
Export Options
About this article
Cite this article as:
Rizkallah Reyad Mariam, Saad Rama and Aziz Karam Ramy, The Human Microbiome Project, Personalized Medicine and the Birth of Pharmacomicrobiomics, Current Pharmacogenomics and Personalized Medicine 2010; 8 (3) . https://dx.doi.org/10.2174/187569210792246326
DOI https://dx.doi.org/10.2174/187569210792246326 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial: “Ah, Wherefore with Infection Should he Live?”: Microbial Virulence Factors in Diabetic Foot Ulceration
Current Vascular Pharmacology A New Binding Site Involving the C-terminal Domain to Design Specific Inhibitors of PepX
Protein & Peptide Letters Noncardiac Surgery: Evaluating and Minimizing Cardiac Risk
Current Cardiology Reviews Editorial (Thematic Issue: From Nuisance to State-of-the-Art: FDG-PET/CT Imaging of Infection and Inflammation)
Current Molecular Imaging (Discontinued) Drug Interactions During Periodontal Therapy in HIV-Infected Subjects
Mini-Reviews in Medicinal Chemistry Editorial [Hot topic: Infective Endocarditis (Guest Editor: Ioannis Starakis)]
Infectious Disorders - Drug Targets Synthesis, Structure and Antibacterial Evaluation of Some N-substituted 3-amino-5-hydroxy-4-phenyl-1H-pyrazole-1-carboxamides
Medicinal Chemistry Probiotics in Intestinal and Non-Intestinal Infectious Diseases – Clinical Evidence
Current Pharmaceutical Design New Developments in Therapeutic Agents for Legionnaires Disease
Anti-Infective Agents in Medicinal Chemistry HtrA Protease Family as Therapeutic Targets
Current Pharmaceutical Design Preface
Recent Patents on Anti-Infective Drug Discovery Current Developments in Anti-Fungal Agents
Current Medicinal Chemistry - Anti-Infective Agents 'Mucormycosis': A Fungal Infection Threatening India During COVID-19' - A Review
Anti-Infective Agents Synthesis and Characterisation of Super-Paramagnetic Iron Oxide Nanoparticles (SPIONs) for Minimising <i>Aeromonas hydrophila</i> Load from Freshwater
Current Nanoscience Brucella as a Potential Agent of Bioterrorism
Recent Patents on Anti-Infective Drug Discovery Enhanced Efficacy of DNA Vaccines Against an Intracellular Bacterial Pathogen by Genetic Adjuvants
Current Pharmaceutical Biotechnology Development and Validation of a UV-Spectrophotometric Method for Determination of Flucloxacillin Sodium in Capsules
Current Pharmaceutical Analysis Hybrid Viral Vectors for Vaccine and Antibody Production in Plants
Current Pharmaceutical Design Staphylococcus aureus: Current State of Prevalence, Impact, and Vaccine Development
Current Pharmaceutical Design Invasive Aspergillosis in Children and Adolescents
Current Pharmaceutical Design