Abstract
The molecular mechanisms that cause physiological aging are still not completely understood, most likely because of the complex nature of the aging process. Recent discoveries on segmental progeroid syndromes emphasize the importance of studying rare diseases to discover more common mechanisms. Since the identification of mutations in the LMNA gene that causes the segmental progeroid syndrome, Hutchinson-Gilford progeria syndrome (HGPS), there has been an increasing interest in the potential role for lamins in the normal aging process. Recent data provide support for the shared mechanisms between natural and pathological aging, and show that further studies of HGPS and segmental progeroid syndromes will be of use in solving the aging puzzle. In this review, we summarize the recent findings and discuss the existing evidence for an important functional link between lamins and the aging process. In addition, we discuss the evidence for a mechanism in which defects in lamins result in genomic instability and senescence.
Keywords: Hutchinson-Gilford progeria syndrome, nuclear lamina, laminopathies, LMNA, mandibuloacral dysplasia, restrictive dermopathy, segmental progeroid syndromes, Werner syndrome
Current Aging Science
Title: Evidence for the Involvement of Lamins in Aging
Volume: 3 Issue: 2
Author(s): Sofia Rodriguez and Maria Eriksson
Affiliation:
Keywords: Hutchinson-Gilford progeria syndrome, nuclear lamina, laminopathies, LMNA, mandibuloacral dysplasia, restrictive dermopathy, segmental progeroid syndromes, Werner syndrome
Abstract: The molecular mechanisms that cause physiological aging are still not completely understood, most likely because of the complex nature of the aging process. Recent discoveries on segmental progeroid syndromes emphasize the importance of studying rare diseases to discover more common mechanisms. Since the identification of mutations in the LMNA gene that causes the segmental progeroid syndrome, Hutchinson-Gilford progeria syndrome (HGPS), there has been an increasing interest in the potential role for lamins in the normal aging process. Recent data provide support for the shared mechanisms between natural and pathological aging, and show that further studies of HGPS and segmental progeroid syndromes will be of use in solving the aging puzzle. In this review, we summarize the recent findings and discuss the existing evidence for an important functional link between lamins and the aging process. In addition, we discuss the evidence for a mechanism in which defects in lamins result in genomic instability and senescence.
Export Options
About this article
Cite this article as:
Rodriguez Sofia and Eriksson Maria, Evidence for the Involvement of Lamins in Aging, Current Aging Science 2010; 3 (2) . https://dx.doi.org/10.2174/1874609811003020081
DOI https://dx.doi.org/10.2174/1874609811003020081 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Subclinical Thyroid Dysfunction and Cardiovascular Outcomes among Prospective Cohort Studies
Endocrine, Metabolic & Immune Disorders - Drug Targets Clinical Implications of Recent Insights into the Structural Biology of Beta2 Adrenoceptors
Current Drug Targets Inflammation Fueling Atrial Fibrillation Substrate: Seeking Ways to "Cool" the Heart
Medicinal Chemistry Molecular Imaging: Its Application In Cardiovascular Diagnosis
Current Pharmaceutical Design Risk Models and Scores of Cardiovascular Disease in Patients with Diabetes Mellitus
Current Pharmaceutical Design Analysis of Captopril in Human Plasma Using Gas Chromatography-Mass Spectrometry (GCMS) with Solid-Phase Extraction (SPE)
Current Analytical Chemistry Ganoderma lucidum: A Potent Pharmacological Macrofungus
Current Pharmaceutical Biotechnology Novel Drugs for Hypertension and Heart Failure: Struggling for a Place Under the Sun
Current Pharmaceutical Design Increased Exercise Favorably Modifies Coronary Artery Disease and Peripheral Arterial Disease Outcomes
Current Vascular Pharmacology Tumor Necrosis Factor Inhibitors as Therapeutic Choice in Psoriasis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry SAR, QSAR and Docking of Anticancer Flavonoids and Variants: A Review
Current Topics in Medicinal Chemistry Recent Patents on Polymeric Scaffolds for Tissue Engineering
Recent Patents on Biomedical Engineering (Discontinued) Cytostatic Effect of the Nucleoside Analogue 2-Chloroadenosine on Human Prostate Cancer Cell Line
Current Pharmaceutical Analysis Noninvasive Diagnosis of Chemotherapy Related Cardiotoxicity
Current Cardiology Reviews Transient Receptor Potential (TRP) Channels and Cardiac Fibrosis
Current Topics in Medicinal Chemistry Benefit of SERCA2a Gene Transfer to Vascular Endothelial and Smooth Muscle Cells: A New Aspect in Therapy of Cardiovascular Diseases
Current Vascular Pharmacology The Coordinated Role of CYP450 Enzymes and P-gp in Determining Cancer Resistance to Chemotherapy
Current Drug Metabolism Drug-Eluting Stents: Present and Future
Cardiovascular & Hematological Agents in Medicinal Chemistry Cyclin-Dependent Kinase 4/6 (Cdk4/6) Inhibitors: Perspectives in Cancer Therapy and Imaging
Mini-Reviews in Medicinal Chemistry Food and Food Supplements with Hypocholesterolemic Effects
Recent Patents on Food, Nutrition & Agriculture