Abstract
Pharmacogenetics (PGt) is a fast evolving field in medical science, since adverse drug reactions (ADR) and therapy failure may be due to variations in the genes of drug metabolizing enzymes, drug transporters and drug targets. There are many different techniques available for the detection of mutations, Single Nucleotide Polymorphisms (SNPs) and gene copy number variations (CNVs) that allow the scientist to apply the best suited method for defined diagnostic questions. This article reviews some of the most important genes of pharmacogenetic relevance, gives an overview of several methods frequently used for genotyping and provides insight into routine pharmacogenetic testing in the clinical laboratory.
Current Pharmacogenomics and Personalized Medicine
Title: Pharmacogenetics in Laboratory Diagnostics
Volume: 6 Issue: 1
Author(s): Birgit Busse and Hanns-Georg Klein
Affiliation:
Abstract: Pharmacogenetics (PGt) is a fast evolving field in medical science, since adverse drug reactions (ADR) and therapy failure may be due to variations in the genes of drug metabolizing enzymes, drug transporters and drug targets. There are many different techniques available for the detection of mutations, Single Nucleotide Polymorphisms (SNPs) and gene copy number variations (CNVs) that allow the scientist to apply the best suited method for defined diagnostic questions. This article reviews some of the most important genes of pharmacogenetic relevance, gives an overview of several methods frequently used for genotyping and provides insight into routine pharmacogenetic testing in the clinical laboratory.
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Cite this article as:
Busse Birgit and Klein Hanns-Georg, Pharmacogenetics in Laboratory Diagnostics, Current Pharmacogenomics and Personalized Medicine 2008; 6 (1) . https://dx.doi.org/10.2174/187569208784017502
DOI https://dx.doi.org/10.2174/187569208784017502 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
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